N-((1S,2S)-7-bromo-2-hydroxy-1,2,3,4-tetrahydronaphthalen-1-yl)-4-fluorobenzamide

Base Information

Chemical Name:N-((1S,2S)-7-bromo-2-hydroxy-1,2,3,4-tetrahydronaphthalen-1-yl)-4-fluorobenzamide
CAS No.:1373215-33-8
Molecular Formula:C₁₇H₁₅BrFNO₂
Molecular Weight:364.214
Hs Code.:

Synonyms:N-((1S,2S)-7-bromo-2-hydroxy-1,2,3,4-tetrahydronaphthalen-1-yl)-4-fluorobenzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-((1S,2S)-7-bromo-2-hydroxy-1,2,3,4-tetrahydronaphthalen-1-yl)-4-fluorobenzamide

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Technology Process of N-((1S,2S)-7-bromo-2-hydroxy-1,2,3,4-tetrahydronaphthalen-1-yl)-4-fluorobenzamide

There total 5 articles about N-((1S,2S)-7-bromo-2-hydroxy-1,2,3,4-tetrahydronaphthalen-1-yl)-4-fluorobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1373215-27-0
(1S,2S)-1-amino-7-bromo-1,2,3,4-tetrahydronaphthalen-2-ol (2S,3S)-2,3-bis(4-methylbenzoyloxy)succinate

: 403-43-0
4-fluorobenzoyl chloride

: 1373215-33-8
N-((1S,2S)-7-bromo-2-hydroxy-1,2,3,4-tetrahydronaphthalen-1-yl)-4-fluorobenzamide

Guidance literature:: With sodium hydrogencarbonate; In tetrahydrofuran; water; at 0 - 5 ℃; for 1h;
DOI:10.1021/ml500283g

Reference yield:

: (+/-)-trans-1-amino-7-bromo-1,2,3,4-tetrahydronaphthalen-2-ol

: 1373215-33-8
N-((1S,2S)-7-bromo-2-hydroxy-1,2,3,4-tetrahydronaphthalen-1-yl)-4-fluorobenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: water; acetonitrile / 0.5 h / 77 °C / Inert atmosphere; Resolution of racemate

2: sodium hydrogencarbonate / water; tetrahydrofuran / 1 h / 0 - 5 °C

With sodium hydrogencarbonate; In tetrahydrofuran; water; acetonitrile;
DOI:10.1021/ml500283g

Reference yield:

: 75693-17-3
bromo-7 dihydro-3,4 naphthalene

: 1373215-33-8
N-((1S,2S)-7-bromo-2-hydroxy-1,2,3,4-tetrahydronaphthalen-1-yl)-4-fluorobenzamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid / water; dichloromethane / 4 h / 0 - 20 °C

2: ammonia / methanol; tetrahydrofuran / 72 h / 70 °C / Sealed tube

3: water; acetonitrile / 0.5 h / 77 °C / Inert atmosphere; Resolution of racemate

4: sodium hydrogencarbonate / water; tetrahydrofuran / 1 h / 0 - 5 °C

With ammonia; sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; methanol; dichloromethane; water; acetonitrile;
DOI:10.1021/ml500283g