methyl 3-({[(tert-butoxycarbonyl)amino][(tert-butoxycarbonyl)imino]methyl}amino)-5-(hydroxymethyl)benzoate

Base Information

Chemical Name:methyl 3-({[(tert-butoxycarbonyl)amino][(tert-butoxycarbonyl)imino]methyl}amino)-5-(hydroxymethyl)benzoate
CAS No.:199536-07-7
Molecular Formula:C₂₀H₂₉N₃O₇
Molecular Weight:423.466
Hs Code.:

Synonyms:methyl 3-({[(tert-butoxycarbonyl)amino][(tert-butoxycarbonyl)imino]methyl}amino)-5-(hydroxymethyl)benzoate

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Chemical Property of methyl 3-({[(tert-butoxycarbonyl)amino][(tert-butoxycarbonyl)imino]methyl}amino)-5-(hydroxymethyl)benzoate

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Technology Process of methyl 3-({[(tert-butoxycarbonyl)amino][(tert-butoxycarbonyl)imino]methyl}amino)-5-(hydroxymethyl)benzoate

There total 4 articles about methyl 3-({[(tert-butoxycarbonyl)amino][(tert-butoxycarbonyl)imino]methyl}amino)-5-(hydroxymethyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 145013-05-4
tert-butyl N-({[(tert-butoxy)carbonyl]amino}methanethioyl)carbamate

: 199536-04-4
3-Amino-5-hydroxymethyl-benzoic acid methyl ester; hydrochloride

: 199536-07-7
methyl 3-({[(tert-butoxycarbonyl)amino][(tert-butoxycarbonyl)imino]methyl}amino)-5-(hydroxymethyl)benzoate

Guidance literature:: With triethylamine; mercury dichloride; In N,N-dimethyl-formamide; for 16h; Ambient temperature;
DOI:10.1021/jm970479e

Reference yield:

: 1955-46-0
5-nitro-1,3-benzenedicarboxylic acid, monomethyl ester

: 199536-07-7
methyl 3-({[(tert-butoxycarbonyl)amino][(tert-butoxycarbonyl)imino]methyl}amino)-5-(hydroxymethyl)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: oxalyl chloride, DMF, pyridine / tetrahydrofuran; acetonitrile / 1 h / -30 °C

2: CuI, LiAlH3)3>3 / tetrahydrofuran; acetonitrile / 0.17 h / -78 °C

3: 78 percent / H₂ / PtO₂ / methanol / 0.5 h / 2585.7 Torr

4: 86 percent / Et₃N, HgCl₂ / dimethylformamide / 16 h / Ambient temperature

With pyridine; copper(l) iodide; oxalyl dichloride; hydrogen; lithium tri-t-butoxyaluminum hydride; triethylamine; N,N-dimethyl-formamide; mercury dichloride; platinum(IV) oxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm970479e

Reference yield:

: 53732-08-4
3-hydroxymethyl-5-nitrobenzoic acid methyl ester

: 199536-07-7
methyl 3-({[(tert-butoxycarbonyl)amino][(tert-butoxycarbonyl)imino]methyl}amino)-5-(hydroxymethyl)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: 78 percent / H₂ / PtO₂ / methanol / 0.5 h / 2585.7 Torr

2: 86 percent / Et₃N, HgCl₂ / dimethylformamide / 16 h / Ambient temperature

With hydrogen; triethylamine; mercury dichloride; platinum(IV) oxide; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm970479e