5-(5-(1-(2-hydroxyethylamino)-2,3-dihydro-1H-inden-4-yl)oxazol-2-yl)-2-isopropoxybenzonitrile

Base Information

Chemical Name:5-(5-(1-(2-hydroxyethylamino)-2,3-dihydro-1H-inden-4-yl)oxazol-2-yl)-2-isopropoxybenzonitrile
CAS No.:1201447-23-5
Molecular Formula:C₂₄H₂₅N₃O₃
Molecular Weight:403.481
Hs Code.:

Synonyms:5-(5-(1-(2-hydroxyethylamino)-2,3-dihydro-1H-inden-4-yl)oxazol-2-yl)-2-isopropoxybenzonitrile

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Chemical Property of 5-(5-(1-(2-hydroxyethylamino)-2,3-dihydro-1H-inden-4-yl)oxazol-2-yl)-2-isopropoxybenzonitrile

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Technology Process of 5-(5-(1-(2-hydroxyethylamino)-2,3-dihydro-1H-inden-4-yl)oxazol-2-yl)-2-isopropoxybenzonitrile

There total 11 articles about 5-(5-(1-(2-hydroxyethylamino)-2,3-dihydro-1H-inden-4-yl)oxazol-2-yl)-2-isopropoxybenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₂H₁₉ClN₂O₂

: 141-43-5
ethanolamine

: 1201447-23-5
5-(5-(1-(2-hydroxyethylamino)-2,3-dihydro-1H-inden-4-yl)oxazol-2-yl)-2-isopropoxybenzonitrile

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In ISOPROPYLAMIDE; at 70 ℃;

Reference yield:

: 15115-60-3
4-bromo-2,3-dihydroinden-1-one

: 1201447-23-5
5-(5-(1-(2-hydroxyethylamino)-2,3-dihydro-1H-inden-4-yl)oxazol-2-yl)-2-isopropoxybenzonitrile

Guidance literature:: Multi-step reaction with 7 steps

1: ethanol; silica gel; sodium tetrahydroborate / 2.33 h / 0 - 20 °C

2: 1H-imidazole / 20 °C

3: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 85 °C / Inert atmosphere

4: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 0.67 h / 100 °C / Inert atmosphere; Microwave irradiation

5: tetrabutyl ammonium fluoride / tetrahydrofuran / 16 h / 0 - 20 °C

6: thionyl chloride / dichloromethane / 3 h / 0 - 20 °C

7: N-ethyl-N,N-diisopropylamine / ISOPROPYLAMIDE / 70 °C

With 1H-imidazole; sodium tetrahydroborate; thionyl chloride; ethanol; tetrabutyl ammonium fluoride; potassium acetate; silica gel; potassium carbonate; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; ISOPROPYLAMIDE; water;

Reference yield:

: 16657-10-6
(±)-4-bromo-2,3-dihydro-1H-inden-1-ol

: 1201447-23-5
5-(5-(1-(2-hydroxyethylamino)-2,3-dihydro-1H-inden-4-yl)oxazol-2-yl)-2-isopropoxybenzonitrile

Guidance literature:: Multi-step reaction with 6 steps

1: 1H-imidazole / 20 °C

2: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 85 °C / Inert atmosphere

3: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 0.67 h / 100 °C / Inert atmosphere; Microwave irradiation

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 16 h / 0 - 20 °C

5: thionyl chloride / dichloromethane / 3 h / 0 - 20 °C

6: N-ethyl-N,N-diisopropylamine / ISOPROPYLAMIDE / 70 °C

With 1H-imidazole; thionyl chloride; tetrabutyl ammonium fluoride; potassium acetate; potassium carbonate; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; ISOPROPYLAMIDE; water;