[(1S)-1-[[2-[trans-4-[tert-butoxycarbonyl-[2-(tert-butoxycarbonylamino)ethyl]amino]cyclohexyl]acetyl]amino]-2-(3-tert-butoxycarbonyl-2-methoxy-phenyl)ethyl]boronic acid (-)-pinanediolato diester

Base Information

Chemical Name:[(1S)-1-[[2-[trans-4-[tert-butoxycarbonyl-[2-(tert-butoxycarbonylamino)ethyl]amino]cyclohexyl]acetyl]amino]-2-(3-tert-butoxycarbonyl-2-methoxy-phenyl)ethyl]boronic acid (-)-pinanediolato diester
CAS No.:1613269-65-0
Molecular Formula:C₄₄H₇₀BN₃O₁₀
Molecular Weight:811.865
Hs Code.:

[(1S)-1-[[2-[trans-4-[tert-butoxycarbonyl-[2-(tert-butoxycarbonylamino)ethyl]amino]cyclohexyl]acetyl]amino]-2-(3-tert-butoxycarbonyl-2-methoxy-phenyl)ethyl]boronic acid (-)-pinanediolato diester

Synonyms:[(1S)-1-[[2-[trans-4-[tert-butoxycarbonyl-[2-(tert-butoxycarbonylamino)ethyl]amino]cyclohexyl]acetyl]amino]-2-(3-tert-butoxycarbonyl-2-methoxy-phenyl)ethyl]boronic acid (-)-pinanediolato diester

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Chemical Property of [(1S)-1-[[2-[trans-4-[tert-butoxycarbonyl-[2-(tert-butoxycarbonylamino)ethyl]amino]cyclohexyl]acetyl]amino]-2-(3-tert-butoxycarbonyl-2-methoxy-phenyl)ethyl]boronic acid (-)-pinanediolato diester

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Technology Process of [(1S)-1-[[2-[trans-4-[tert-butoxycarbonyl-[2-(tert-butoxycarbonylamino)ethyl]amino]cyclohexyl]acetyl]amino]-2-(3-tert-butoxycarbonyl-2-methoxy-phenyl)ethyl]boronic acid (-)-pinanediolato diester

There total 8 articles about [(1S)-1-[[2-[trans-4-[tert-butoxycarbonyl-[2-(tert-butoxycarbonylamino)ethyl]amino]cyclohexyl]acetyl]amino]-2-(3-tert-butoxycarbonyl-2-methoxy-phenyl)ethyl]boronic acid (-)-pinanediolato diester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1613269-64-9
2-(trans-4-((tert-butoxycarbonyl)(2-((tert-butoxycarbonyl)amino)ethyl)amino)cyclohexyl)acetic acid

: 1613269-66-1
[(1S)-1-[bis(trimethylsilyl)amino]-2-(3-tert-butoxycarbonyl-2-methoxy-phenyl)ethyl]boronic acid (-) pinandiolato diester

: 1613269-65-0
[(1S)-1-[[2-[trans-4-[tert-butoxycarbonyl-[2-(tert-butoxycarbonylamino)ethyl]amino]cyclohexyl]acetyl]amino]-2-(3-tert-butoxycarbonyl-2-methoxy-phenyl)ethyl]boronic acid (-)-pinanediolato diester

Guidance literature:: 2-(trans-4-((tert-butoxycarbonyl)(2-((tert-butoxycarbonyl)amino)ethyl)amino)cyclohexyl)acetic acid; With 4-methyl-morpholine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl acetamide; for 1.5h;

[(1S)-1-[bis(trimethylsilyl)amino]-2-(3-tert-butoxycarbonyl-2-methoxy-phenyl)ethyl]boronic acid (-) pinandiolato diester; In tetrahydrofuran; N,N-dimethyl acetamide; for 4h;

Reference yield:

: 1613269-59-2
3-iodo-2-methoxybenzoic acid tert-butyl ester

: 1613269-65-0
[(1S)-1-[[2-[trans-4-[tert-butoxycarbonyl-[2-(tert-butoxycarbonylamino)ethyl]amino]cyclohexyl]acetyl]amino]-2-(3-tert-butoxycarbonyl-2-methoxy-phenyl)ethyl]boronic acid (-)-pinanediolato diester

Guidance literature:: Multi-step reaction with 4 steps

1.1: TurboGrignard / tetrahydrofuran / 0.33 h / -40 °C

1.2: 0.75 h / -78 °C

1.3: 2 h

2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -100 °C

2.2: 1.13 h / -100 - -10 °C

3.1: tetrahydrofuran / 1 h / -20 °C

4.1: 4-methyl-morpholine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl acetamide / 1.5 h

4.2: 4 h

With 4-methyl-morpholine; TurboGrignard; n-butyllithium; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; hexane; N,N-dimethyl acetamide;

Reference yield:

: 874347-49-6
3-iodo-2-methoxy-benzaldehyde

: 1613269-65-0
[(1S)-1-[[2-[trans-4-[tert-butoxycarbonyl-[2-(tert-butoxycarbonylamino)ethyl]amino]cyclohexyl]acetyl]amino]-2-(3-tert-butoxycarbonyl-2-methoxy-phenyl)ethyl]boronic acid (-)-pinanediolato diester

Guidance literature:: Multi-step reaction with 7 steps

1.1: 2,3-Dimethyl-2-butene; disodium hydrogen phosphate monohydrate; sodium chlorite / water; tert-butyl alcohol / 0.33 h

2.1: thionyl chloride / 0.5 h / 82 °C

3.1: n-butyllithium / tetrahydrofuran; hexane / 0.33 h / -5 °C

3.2: 1.5 h

4.1: TurboGrignard / tetrahydrofuran / 0.33 h / -40 °C

4.2: 0.75 h / -78 °C

4.3: 2 h

5.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -100 °C

5.2: 1.13 h / -100 - -10 °C

6.1: tetrahydrofuran / 1 h / -20 °C

7.1: 4-methyl-morpholine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl acetamide / 1.5 h

7.2: 4 h

With 4-methyl-morpholine; sodium chlorite; TurboGrignard; n-butyllithium; thionyl chloride; 2,3-Dimethyl-2-butene; disodium hydrogen phosphate monohydrate; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; hexane; N,N-dimethyl acetamide; water; tert-butyl alcohol;