diethyl N-<4-<2-(2,4-diamino-5-deaza-6-pteridyl)ethyl>benzoyl>-L-glutamate

Base Information

Chemical Name:diethyl N-<4-<2-(2,4-diamino-5-deaza-6-pteridyl)ethyl>benzoyl>-L-glutamate
CAS No.:95674-69-4
Molecular Formula:C₂₅H₃₀N₆O₅
Molecular Weight:494.55
Hs Code.:

Synonyms:diethyl N-<4-<2-(2,4-diamino-5-deaza-6-pteridyl)ethyl>benzoyl>-L-glutamate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of diethyl N-<4-<2-(2,4-diamino-5-deaza-6-pteridyl)ethyl>benzoyl>-L-glutamate

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Technology Process of diethyl N-<4-<2-(2,4-diamino-5-deaza-6-pteridyl)ethyl>benzoyl>-L-glutamate

There total 16 articles about diethyl N-<4-<2-(2,4-diamino-5-deaza-6-pteridyl)ethyl>benzoyl>-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: diethyl N-(4-[2-(2,4-diaminopyrido[2,3-d]pyrimidin-6-yl)ethenyl]benzoyl)-L-glutamate

: 497-19-8
sodium carbonate

: diethyl N-[4-[2-(2,4-diamino-5-deaza-6-pteridyl)ethyl]benzoyl]-L-glutamate

: 95674-69-4
diethyl N-<4-<2-(2,4-diamino-5-deaza-6-pteridyl)ethyl>benzoyl>-L-glutamate

Guidance literature:: With hydrogen; palladium-carbon; In water; trifluoroacetic acid;

Reference yield:

: 95674-67-2
diethyl N-<4-<2-(2,4-diamino-5-deaza-6-pteridyl)ethenyl>benzoyl>-L-glutamate

: 95674-69-4
diethyl N-<4-<2-(2,4-diamino-5-deaza-6-pteridyl)ethyl>benzoyl>-L-glutamate

: 95693-79-1
diethyl N-<4-<2-(2,4-diamino-5-deaza-5,6,7,8-tetrahydro-6-pteridyl)ethyl>benzoyl>-L-glutamate

Guidance literature:: With hydrogen; trifluoroacetic acid; palladium on activated charcoal; for 24h; under 2844.3 Torr;
DOI:10.1021/jm00145a012

Reference yield:

: 95674-65-0
2,4-diamino-6-<4-(tert-butoxycarbonyl)styryl>-5-deazapteridine

: 95674-69-4
diethyl N-<4-<2-(2,4-diamino-5-deaza-6-pteridyl)ethyl>benzoyl>-L-glutamate

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / HCl / nitromethane / 1 h / 0 °C

2: 1.) diphenyl chlorophosphonate, N-methyl-pyrrolidone, N-methylmorpholine / 1.) 5 deg C, 1 h, 2.) RT, overnight

3: 58 percent / TFA, H₂ / Pd/C / 24 h / 2844.3 Torr

With 4-methyl-morpholine; 1-methyl-pyrrolidin-2-one; hydrogenchloride; hydrogen; chlorophosphoric acid diphenyl ester; trifluoroacetic acid; palladium on activated charcoal; In nitromethane;
DOI:10.1021/jm00145a012