Technology Process of (1R)-1(triphenylmethoxy)cyclohex-2-ene
There total 3 articles about (1R)-1(triphenylmethoxy)cyclohex-2-ene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
1,8-diazabicyclo[5.4.0]undec-7-ene;
In
dichloromethane;
at 20 ℃;
for 45h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: borane N,N-diethylaniline complex; Trimethyl borate; (S)-diphenylprolinol / tetrahydrofuran / 3.75 h / -10 - 0 °C / Inert atmosphere
2.1: tert.-butyl lithium / diethyl ether; pentane / 4.5 h / -78 - -20 °C / Inert atmosphere
2.2: 1 h / -20 - 20 °C
3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 45 h / 20 °C
With
borane N,N-diethylaniline complex; Trimethyl borate; (S)-diphenylprolinol; tert.-butyl lithium; 1,8-diazabicyclo[5.4.0]undec-7-ene;
In
tetrahydrofuran; diethyl ether; dichloromethane; pentane;
DOI:10.1002/chem.201102884
- Guidance literature:
-
Multi-step reaction with 4 steps
1: bromine / dichloromethane / 2.5 - 3.08 h / 0 °C
2: Trimethyl borate; (S)-diphenylprolinol; boron trifluoride; N,N-diethylaniline / tetrahydrofuran / 3 h / 0 °C
3: tert.-butyl lithium / diethyl ether / 3 h / -20 °C
4: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 45 - 48 h / 20 °C
With
Trimethyl borate; (S)-diphenylprolinol; boron trifluoride; bromine; tert.-butyl lithium; 1,8-diazabicyclo[5.4.0]undec-7-ene; N,N-diethylaniline;
In
tetrahydrofuran; diethyl ether; dichloromethane;
