2,2'-dimethoxy-5,5'-dibromodiphenyl ether

Base Information

• Chemical Name: 2,2'-dimethoxy-5,5'-dibromodiphenyl ether
• CAS No.: 159163-67-4
• Molecular Formula: C₁₄H₁₂Br₂O₃
• Molecular Weight: 388.055
• Mol file: 159163-67-4.mol

Synonyms:2,2'-dimethoxy-5,5'-dibromodiphenyl ether

Chemical Property of 2,2'-dimethoxy-5,5'-dibromodiphenyl ether

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 2,2'-dimethoxy-5,5'-dibromodiphenyl ether

There total 1 articles about 2,2'-dimethoxy-5,5'-dibromodiphenyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

2,2'-dihydroxy-5,5'-dibromodiphenyl ether (22649-30-5) + methyl iodide (74-88-4) → 2,2'-dimethoxy-5,5'-dibromodiphenyl ether (159163-67-4)

Guidance literature:

With sodium hydride; In tetrahydrofuran; for 36h; Heating;

DOI:10.1021/ja00090a004

Reference yield: 73.0%

Trimethyl borate (121-43-7,63156-11-6) + 2,2'-dimethoxy-5,5'-dibromodiphenyl ether (159163-67-4) → O{C6H3(B(OH)2)(OCH3)}2 (159163-68-5)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; hexane; a soln. of n-BuLi in hexane is added to a stirred soln.of the bromide in THF at 75°C under N2, after 2 h this soln. is dropped into a soln. of B(OMe)3 in THF at -75°C, the temp. is raised to room temp., stirred for 18 h; the solvent is removed, the residue is washed (water, hexane), recrystd. (methanol-water), elem. anal.;

DOI:10.1021/ja00090a004

Reference yield: 62.0%

2,2'-dimethoxy-5,5'-dibromodiphenyl ether (159163-67-4) + bis(pinacol)diborane (73183-34-3) → C26H36B2O7

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; In 1,4-dioxane; at 80 ℃; for 24h; Inert atmosphere;

DOI:10.1002/anie.202002646

upstream raw materials:

2,2'-dihydroxy-5,5'-dibromodiphenyl ether

methyl iodide

Downstream raw materials:

O{C₆H₃(B(OH)2)(OCH₃)}2