9-chloro-7-(o-fluorophenyl)-5H-dibenzazepine

Base Information

Chemical Name:9-chloro-7-(o-fluorophenyl)-5H-dibenzazepine
CAS No.:81537-93-1
Molecular Formula:C₂₀H₁₃ClFN
Molecular Weight:321.781
Hs Code.:

9-chloro-7-(o-fluorophenyl)-5H-dibenz<c,e>azepine

Synonyms:9-chloro-7-(o-fluorophenyl)-5H-dibenzazepine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 9-chloro-7-(o-fluorophenyl)-5H-dibenzazepine

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Technology Process of 9-chloro-7-(o-fluorophenyl)-5H-dibenzazepine

There total 36 articles about 9-chloro-7-(o-fluorophenyl)-5H-dibenzazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 114049-90-0
N-<2-4-(chlorophenyl)benzyl>-2-fluorobenzimidoyl chloride

: 81537-93-1
9-chloro-7-(o-fluorophenyl)-5H-dibenzazepine

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; 1.) 0 deg C, 10 min, 2.) room temperature, 30 min;

Reference yield:

: 3438-16-2
5-chloro-2-methoxybenzoic acid

: 81537-93-1
9-chloro-7-(o-fluorophenyl)-5H-dibenzazepine

Guidance literature:: Multi-step reaction with 7 steps

1: SOCl₂ / 0.5 h / Ambient temperature

2: sodium carbonate / CH₂Cl₂; H₂O / 4 h

3: 1.) thionyl chloride, 2.) 50percent sodium hydroxide / 2.) tetrabutylammonium hydrogen sulfate / 1.) RT, 80 min, 2.) methylene chloride, water, RT, 2 h

4: 1.) Mg / 1.) ether, 2.) THF, RT, 16 h

5: 75 percent / cyanogen bromide / CH₂Cl₂ / 16 h / Ambient temperature

6: 72 percent / potassium tert-butoxide / xylene / 1.5 h / Heating

7: 1.) n-BuLi / 1.) hexane, ether, -70 deg C, 10 min, 2.) THF, RT, 16 h

With sodium hydroxide; n-butyllithium; thionyl chloride; bromocyane; potassium tert-butylate; sodium carbonate; magnesium; tetra(n-butyl)ammonium hydrogensulfate; In dichloromethane; water; xylene;
DOI:10.1021/jo00140a012

Reference yield:

: 29568-33-0
2-methoxy-5-chlorobenzoyl chloride

: 81537-93-1
9-chloro-7-(o-fluorophenyl)-5H-dibenzazepine

Guidance literature:: Multi-step reaction with 6 steps

1: sodium carbonate / CH₂Cl₂; H₂O / 4 h

2: 1.) thionyl chloride, 2.) 50percent sodium hydroxide / 2.) tetrabutylammonium hydrogen sulfate / 1.) RT, 80 min, 2.) methylene chloride, water, RT, 2 h

3: 1.) Mg / 1.) ether, 2.) THF, RT, 16 h

4: 75 percent / cyanogen bromide / CH₂Cl₂ / 16 h / Ambient temperature

5: 72 percent / potassium tert-butoxide / xylene / 1.5 h / Heating

6: 1.) n-BuLi / 1.) hexane, ether, -70 deg C, 10 min, 2.) THF, RT, 16 h

With sodium hydroxide; n-butyllithium; thionyl chloride; bromocyane; potassium tert-butylate; sodium carbonate; magnesium; tetra(n-butyl)ammonium hydrogensulfate; In dichloromethane; water; xylene;
DOI:10.1021/jo00140a012