6-bromo-2-(4-fluorophenyl)-imidazo[1,2-a]pyridine-3-carbaldehyde-O-prop-2-ynyl oxime

Base Information

Chemical Name:6-bromo-2-(4-fluorophenyl)-imidazo[1,2-a]pyridine-3-carbaldehyde-O-prop-2-ynyl oxime
CAS No.:1435396-25-0
Molecular Formula:C₁₇H₁₁BrFN₃O
Molecular Weight:372.196
Hs Code.:

Synonyms:6-bromo-2-(4-fluorophenyl)-imidazo[1,2-a]pyridine-3-carbaldehyde-O-prop-2-ynyl oxime

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-bromo-2-(4-fluorophenyl)-imidazo[1,2-a]pyridine-3-carbaldehyde-O-prop-2-ynyl oxime

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Technology Process of 6-bromo-2-(4-fluorophenyl)-imidazo[1,2-a]pyridine-3-carbaldehyde-O-prop-2-ynyl oxime

There total 5 articles about 6-bromo-2-(4-fluorophenyl)-imidazo[1,2-a]pyridine-3-carbaldehyde-O-prop-2-ynyl oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1435395-83-7
6-bromo-2-(4-fluorophenyl)imidazo[1,2-a]pyridine-3-carbaldehyde oxime

: 106-96-7
propargyl bromide

: 1435396-25-0
6-bromo-2-(4-fluorophenyl)-imidazo[1,2-a]pyridine-3-carbaldehyde-O-prop-2-ynyl oxime

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 25 - 30 ℃; for 4h;
DOI:10.1016/j.bmcl.2013.03.086

Reference yield:

: 1072-97-5
5-bromo-2-pyridylamine

: 1435396-25-0
6-bromo-2-(4-fluorophenyl)-imidazo[1,2-a]pyridine-3-carbaldehyde-O-prop-2-ynyl oxime

Guidance literature:: Multi-step reaction with 4 steps

1.1: ethanol / 6 h / Reflux

2.1: trichlorophosphate / 0 - 5 °C

2.2: 6 h / 80 °C

3.1: hydroxylamine hydrochloride; sulfuric acid / ethanol / 4 h / Reflux

4.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 25 - 30 °C

With sulfuric acid; hydroxylamine hydrochloride; potassium carbonate; trichlorophosphate; In ethanol; N,N-dimethyl-formamide; 2.1: |Vilsmeier-Haack Formylation;
DOI:10.1016/j.bmcl.2013.03.086

Reference yield:

: 403-29-2
2-bromo-4'-fluoroacetophenone

: 1435396-25-0
6-bromo-2-(4-fluorophenyl)-imidazo[1,2-a]pyridine-3-carbaldehyde-O-prop-2-ynyl oxime

Guidance literature:: Multi-step reaction with 4 steps

1.1: ethanol / 6 h / Reflux

2.1: trichlorophosphate / 0 - 5 °C

2.2: 6 h / 80 °C

3.1: hydroxylamine hydrochloride; sulfuric acid / ethanol / 4 h / Reflux

4.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 25 - 30 °C

With sulfuric acid; hydroxylamine hydrochloride; potassium carbonate; trichlorophosphate; In ethanol; N,N-dimethyl-formamide; 2.1: |Vilsmeier-Haack Formylation;
DOI:10.1016/j.bmcl.2013.03.086