2,2,2-trichloroethyl 1-(4-(benzyloxy)phenyl)-2-(2,4-dichlorophenyl)-5-methyl-1H-imidazole-4-carboxylate

Base Information

Chemical Name:2,2,2-trichloroethyl 1-(4-(benzyloxy)phenyl)-2-(2,4-dichlorophenyl)-5-methyl-1H-imidazole-4-carboxylate
CAS No.:930283-42-4
Molecular Formula:C₂₆H₁₉Cl₅N₂O₃
Molecular Weight:584.713
Hs Code.:

Synonyms:2,2,2-trichloroethyl 1-(4-(benzyloxy)phenyl)-2-(2,4-dichlorophenyl)-5-methyl-1H-imidazole-4-carboxylate

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Chemical Property of 2,2,2-trichloroethyl 1-(4-(benzyloxy)phenyl)-2-(2,4-dichlorophenyl)-5-methyl-1H-imidazole-4-carboxylate

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Technology Process of 2,2,2-trichloroethyl 1-(4-(benzyloxy)phenyl)-2-(2,4-dichlorophenyl)-5-methyl-1H-imidazole-4-carboxylate

There total 5 articles about 2,2,2-trichloroethyl 1-(4-(benzyloxy)phenyl)-2-(2,4-dichlorophenyl)-5-methyl-1H-imidazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1-(4-benzyloxyphenyl)-2-(2,4-dichlorophenyl)-5-methyl-1H-imidazole-4-carboxylic acid chloride

: 115-20-8
1,1,1-trichloroethanol

: 930283-42-4
2,2,2-trichloroethyl 1-(4-(benzyloxy)phenyl)-2-(2,4-dichlorophenyl)-5-methyl-1H-imidazole-4-carboxylate

Guidance literature:: With dmap; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 3h;

Reference yield:

: 866598-56-3
ethyl 1-(4-(benzyloxy)phenyl)-2-(2,4-dichlorophenyl)-5-methyl-1H-imidazole-4-carboxylate

: 930283-42-4
2,2,2-trichloroethyl 1-(4-(benzyloxy)phenyl)-2-(2,4-dichlorophenyl)-5-methyl-1H-imidazole-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: water; potassium hydroxide / methanol / 2 h / Reflux

2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / Reflux

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.67 h / 0 - 20 °C

3.2: 1.33 h

With oxalyl dichloride; water; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; potassium hydroxide; In methanol; dichloromethane;
DOI:10.1021/acs.jmedchem.7b00861

Reference yield:

: 6373-46-2
p-benzyloxyaniline

: 930283-42-4
2,2,2-trichloroethyl 1-(4-(benzyloxy)phenyl)-2-(2,4-dichlorophenyl)-5-methyl-1H-imidazole-4-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: ethylmagnesium bromide / tetrahydrofuran / 0.33 h / Inert atmosphere

1.2: 20 h / 20 °C / Inert atmosphere

2.1: potassium carbonate / tetrahydrofuran / 0.17 h

2.2: 67 h / 20 °C

3.1: water; potassium hydroxide / methanol / 2 h / Reflux

4.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / Reflux

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.67 h / 0 - 20 °C

5.2: 1.33 h

With oxalyl dichloride; ethylmagnesium bromide; water; potassium carbonate; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; potassium hydroxide; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/acs.jmedchem.7b00861