(5-{2-[2-(2,4-Difluoro-phenyl)-2H-[1,2,4]triazol-3-yl]-4,5-dihydro-6-oxa-1-thia-10-aza-benzo[e]azulen-9-yl}-pyridin-2-yl)-(2-methanesulfonyl-ethyl)-amine

Base Information

Chemical Name:(5-{2-[2-(2,4-Difluoro-phenyl)-2H-[1,2,4]triazol-3-yl]-4,5-dihydro-6-oxa-1-thia-10-aza-benzo[e]azulen-9-yl}-pyridin-2-yl)-(2-methanesulfonyl-ethyl)-amine
CAS No.:1282525-83-0
Molecular Formula:C₂₇H₂₂F₂N₆O₃S₂
Molecular Weight:580.639
Hs Code.:

Synonyms:(5-{2-[2-(2,4-Difluoro-phenyl)-2H-[1,2,4]triazol-3-yl]-4,5-dihydro-6-oxa-1-thia-10-aza-benzo[e]azulen-9-yl}-pyridin-2-yl)-(2-methanesulfonyl-ethyl)-amine

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Chemical Property of (5-{2-[2-(2,4-Difluoro-phenyl)-2H-[1,2,4]triazol-3-yl]-4,5-dihydro-6-oxa-1-thia-10-aza-benzo[e]azulen-9-yl}-pyridin-2-yl)-(2-methanesulfonyl-ethyl)-amine

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Technology Process of (5-{2-[2-(2,4-Difluoro-phenyl)-2H-[1,2,4]triazol-3-yl]-4,5-dihydro-6-oxa-1-thia-10-aza-benzo[e]azulen-9-yl}-pyridin-2-yl)-(2-methanesulfonyl-ethyl)-amine

There total 11 articles about (5-{2-[2-(2,4-Difluoro-phenyl)-2H-[1,2,4]triazol-3-yl]-4,5-dihydro-6-oxa-1-thia-10-aza-benzo[e]azulen-9-yl}-pyridin-2-yl)-(2-methanesulfonyl-ethyl)-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 4.1%

: 49773-20-8
2-Methanesulfonyl-ethylamine

: 1282525-58-9
2-[2-(2,4-Difluoro-phenyl)-2H-[1,2,4]triazol-3-yl]-9-[6-(4-methyl-piperazin-1-yl)-pyridin-3-yl]-4,5-dihydro-6-oxa-1-thia-10-aza-benzo[e]azulene

: 1282525-83-0
(5-{2-[2-(2,4-Difluoro-phenyl)-2H-[1,2,4]triazol-3-yl]-4,5-dihydro-6-oxa-1-thia-10-aza-benzo[e]azulen-9-yl}-pyridin-2-yl)-(2-methanesulfonyl-ethyl)-amine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; at 150 ℃; for 2h; Sealed tube; Inert atmosphere; Microwave irradiation;

Reference yield:

: 6964-21-2
thiophen-3-yl-acetic acid

: 1282525-83-0
(5-{2-[2-(2,4-Difluoro-phenyl)-2H-[1,2,4]triazol-3-yl]-4,5-dihydro-6-oxa-1-thia-10-aza-benzo[e]azulen-9-yl}-pyridin-2-yl)-(2-methanesulfonyl-ethyl)-amine

Guidance literature:: Multi-step reaction with 10 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C

2.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 20 °C

3.1: potassium carbonate; tetraethylammonium chloride / triphenylphosphine; palladium diacetate / acetonitrile / 3 h / 80 °C / Inert atmosphere

4.1: N-Bromosuccinimide; acetic acid / dichloromethane / 0 - 5 °C

5.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C

5.2: -78 °C

6.1: N-ethyl-N,N-diisopropylamine; ammonium chloride; HATU / N,N-dimethyl-formamide / 20 °C

7.1: toluene / 2 h / 90 °C

7.2: 2 h / 90 °C

8.1: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / acetonitrile; water / 1 h / 80 °C / Inert atmosphere; Sealed tube

9.1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 2 h / 150 °C / Inert atmosphere; Sealed tube; Microwave irradiation

10.1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 2 h / 150 °C / Sealed tube; Inert atmosphere; Microwave irradiation

With N-Bromosuccinimide; lithium aluminium tetrahydride; n-butyllithium; di-isopropyl azodicarboxylate; tetraethylammonium chloride; potassium carbonate; ammonium chloride; caesium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium diacetate; triphenylphosphine; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; hexane; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile; 8.1: Suzuki Coupling;

Reference yield:

: 1189812-87-0
9-Chloro-2-[2-(2,4-difluoro-phenyl)-2H-[1,2,4]triazol-3-yl]-4,5-dihydro-6-oxa-1-thia-10-aza-benzo[e]azulene

: 1282525-83-0
(5-{2-[2-(2,4-Difluoro-phenyl)-2H-[1,2,4]triazol-3-yl]-4,5-dihydro-6-oxa-1-thia-10-aza-benzo[e]azulen-9-yl}-pyridin-2-yl)-(2-methanesulfonyl-ethyl)-amine

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / acetonitrile; water / 1 h / 80 °C / Inert atmosphere; Sealed tube

2: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 2 h / 150 °C / Inert atmosphere; Sealed tube; Microwave irradiation

3: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 2 h / 150 °C / Sealed tube; Inert atmosphere; Microwave irradiation

With caesium carbonate; N-ethyl-N,N-diisopropylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1-methyl-pyrrolidin-2-one; water; acetonitrile; 1: Suzuki Coupling;