Benzenemethanamine, N-(3-chlorophenyl)-a-methyl-

Base Information

• Chemical Name: Benzenemethanamine, N-(3-chlorophenyl)-a-methyl-
• CAS No.: 109240-37-1
• Molecular Formula: C₁₄H₁₄ClN
• Molecular Weight: 231.725
• Mol file: 109240-37-1.mol

Synonyms:Benzenemethanamine, N-(3-chlorophenyl)-a-methyl-

Chemical Property of Benzenemethanamine, N-(3-chlorophenyl)-a-methyl-

Chemical Property:

• Vapor Pressure: 5.42E-05mmHg at 25°C
• Refractive Index: 1.62
• Boiling Point: 347.3°Cat760mmHg
• Flash Point: 163.9°C
• PSA: 12.03000
• Density: 1.165g/cm³
• LogP: 4.58610

Purity/Quality:

98%min ^*data from raw suppliers

N-(3-CHLOROPHENYL)-ALPHA-METHYL-BENZENEMETHANAMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzenemethanamine, N-(3-chlorophenyl)-a-methyl-

There total 7 articles about Benzenemethanamine, N-(3-chlorophenyl)-a-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

phenylacetylene (536-74-3) + 3-chloro-aniline (108-42-9) → N-α-phenylethyl-m-chloroaniline (109240-37-1)

Guidance literature:

phenylacetylene; 3-chloro-aniline; With indium(III) bromide; In toluene; at 110 ℃; for 3h; Inert atmosphere;

With Dimethylphenylsilane; In toluene; at 60 ℃; for 20h;

DOI:10.1002/ejoc.201402544

Reference yield: 81.0%

acetophenone (98-86-2) + 3-chloro-aniline (108-42-9) → N-α-phenylethyl-m-chloroaniline (109240-37-1)

Guidance literature:

With diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; S-benzyl isothiouronium chloride; In toluene; at 20 ℃; for 24h; Molecular sieve; Inert atmosphere; Reflux;

DOI:10.1055/s-0031-1291125

Reference yield: 56.0%

styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) + 3-Nitrochlorobenzene (121-73-3) → N-α-phenylethyl-m-chloroaniline (109240-37-1)

Guidance literature:

With Triethoxysilane; C₂₅H₂₂FeNPS; In tetrahydrofuran; at 40 ℃; for 24h;

DOI:10.1021/acscatal.9b03604

upstream raw materials:

acetophenone

3-chloro-aniline

phenylacetylene

3-chloro-N-(1-phenylethylidene)aniline

Refernces

• 1、 Song, Heng,Yang, Zhuoyi,Tung, Chen-Ho,Wang, Wenguang. "Iron-catalyzed reductive coupling of nitroarenes with olefins: Intermediate of iron-nitroso complex". . p. 276 - 281. Retrieved 2019/12/24.
• 2、 Ge, Xin,Qian, Chao,Ye, Xiaoming,Chen, Xinzhi. "Asymmetric reduction of imines with trichlorosilane catalyzed by valine-derived formamide immobilized onto magnetic nano-Fe3O4". . p. 65402 - 65407. Retrieved 2015/08/18.