Diethyl N-pyrimidin-6-yl)methyl)-10-formyl-4-(aminomethyl)benzoyl>glutamate

Base Information

Chemical Name:Diethyl N-pyrimidin-6-yl)methyl)-10-formyl-4-(aminomethyl)benzoyl>glutamate
CAS No.:126405-46-7
Molecular Formula:C₃₁H₃₈N₆O₈
Molecular Weight:622.678
Hs Code.:

Diethyl N-<N-((2-(pivaloylamino)-3,4-dihydro-4-oxopyrido<2,3-d>pyrimidin-6-yl)methyl)-10-formyl-4-(aminomethyl)benzoyl>glutamate

Synonyms:Diethyl N-pyrimidin-6-yl)methyl)-10-formyl-4-(aminomethyl)benzoyl>glutamate

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Chemical Property of Diethyl N-pyrimidin-6-yl)methyl)-10-formyl-4-(aminomethyl)benzoyl>glutamate

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Technology Process of Diethyl N-pyrimidin-6-yl)methyl)-10-formyl-4-(aminomethyl)benzoyl>glutamate

There total 6 articles about Diethyl N-pyrimidin-6-yl)methyl)-10-formyl-4-(aminomethyl)benzoyl>glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 126405-45-6
Diethyl N-[N-(2-Pivaloylamino-4-hydroxypyrido[2,3-d]-pyrimidin-6-ylmethyl)-4-aminomethylbenzoyl]-glutamate

: 126405-46-7
diethyl N-[N-(2-pivaloylamino-4-hydroxypyrido[2,3-d]pyrimidin-6-ylmethyl)-N-formyl-4-aminomethylbenzoyl]-glutamate

Guidance literature:: With acetic anhydride; sodium hydrogencarbonate; In formic acid; dichloromethane;

Reference yield:

: 16450-41-2
L-glutamic acid diethyl ester

: 126405-46-7
Diethyl N-pyrimidin-6-yl)methyl)-10-formyl-4-(aminomethyl)benzoyl>glutamate

Guidance literature:: Multi-step reaction with 4 steps

1: 59 percent / Et₃N, 4-(dimethylamino)pyridine, DCC / 1.) 0 deg C, 1 h, 2.) r.t., 18 h

2: AcONa / acetic acid / 18 h / 25 °C

3: BH₃*Et₃N / acetic acid / 2 h / 25 °C

4: Ac₂O / 1 h / 25 °C

With dmap; triethylamine-borane; sodium acetate; acetic anhydride; triethylamine; dicyclohexyl-carbodiimide; In acetic acid;
DOI:10.1021/jo00102a039

Reference yield:

: 244289-94-9
N-((o-Nitrophenyl)sulfenyl)-4-(aminomethyl)benzoic acid

: 126405-46-7
Diethyl N-pyrimidin-6-yl)methyl)-10-formyl-4-(aminomethyl)benzoyl>glutamate

Guidance literature:: Multi-step reaction with 4 steps

1: 59 percent / Et₃N, 4-(dimethylamino)pyridine, DCC / 1.) 0 deg C, 1 h, 2.) r.t., 18 h

2: AcONa / acetic acid / 18 h / 25 °C

3: BH₃*Et₃N / acetic acid / 2 h / 25 °C

4: Ac₂O / 1 h / 25 °C

With dmap; triethylamine-borane; sodium acetate; acetic anhydride; triethylamine; dicyclohexyl-carbodiimide; In acetic acid;
DOI:10.1021/jo00102a039