(1R,3aR,7aR)-1-[(S)-2-(4-Methoxy-benzyloxy)-1-methyl-ethyl]-3a-methoxymethoxy-7a-methyl-octahydro-inden-4-one

Base Information

Chemical Name:(1R,3aR,7aR)-1-[(S)-2-(4-Methoxy-benzyloxy)-1-methyl-ethyl]-3a-methoxymethoxy-7a-methyl-octahydro-inden-4-one
CAS No.:908255-73-2
Molecular Formula:C₂₃H₃₄O₅
Molecular Weight:390.52
Hs Code.:

Synonyms:(1R,3aR,7aR)-1-[(S)-2-(4-Methoxy-benzyloxy)-1-methyl-ethyl]-3a-methoxymethoxy-7a-methyl-octahydro-inden-4-one

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Chemical Property of (1R,3aR,7aR)-1-[(S)-2-(4-Methoxy-benzyloxy)-1-methyl-ethyl]-3a-methoxymethoxy-7a-methyl-octahydro-inden-4-one

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Technology Process of (1R,3aR,7aR)-1-[(S)-2-(4-Methoxy-benzyloxy)-1-methyl-ethyl]-3a-methoxymethoxy-7a-methyl-octahydro-inden-4-one

There total 9 articles about (1R,3aR,7aR)-1-[(S)-2-(4-Methoxy-benzyloxy)-1-methyl-ethyl]-3a-methoxymethoxy-7a-methyl-octahydro-inden-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 908255-72-1
(1R,3aR,4R,7aR)-1-[(S)-2-(4-Methoxy-benzyloxy)-1-methyl-ethyl]-3a-methoxymethoxy-7a-methyl-octahydro-inden-4-ol

: 908255-73-2
(1R,3aR,7aR)-1-[(S)-2-(4-Methoxy-benzyloxy)-1-methyl-ethyl]-3a-methoxymethoxy-7a-methyl-octahydro-inden-4-one

Guidance literature:: With tetrapropylammonium perruthennate; 4 A molecular sieve; 4-methylmorpholine N-oxide; In dichloromethane; at 20 ℃; for 3h;
DOI:10.1021/jo0608725

Reference yield:

: 908255-69-6
(S)-2-((1R,7aR)-7a-Methyl-2,3,5,6,7,7a-hexahydro-1H-inden-1-yl)-propan-1-ol

: 908255-73-2
(1R,3aR,7aR)-1-[(S)-2-(4-Methoxy-benzyloxy)-1-methyl-ethyl]-3a-methoxymethoxy-7a-methyl-octahydro-inden-4-one

Guidance literature:: Multi-step reaction with 7 steps

1: 74 percent / tetrabutylammonium iodide; NaH / tetrahydrofuran / 18 h / Heating

2: 0.308 g / m-chloroperoxybenzoic acid / CH₂Cl₂ / 2 h / -15 °C

3: 0.192 g / KOH / dimethylsulfoxide; H₂O / 18 h / 140 °C

4: triethylamine / tetrahydrofuran / 4 h / 20 °C

5: 4-(dimethylamino)pyridine; N,N-diisopropylethylamine / CH₂Cl₂ / 72 h / 20 °C

6: 1.17 g / tetrabutylammonium fluoride / tetrahydrofuran / 1 h / 20 °C

7: 98 percent / tetrapropylammonium perruthenate; 4-methylmorpholine N-oxide; molecular sieves 4 Angstroem / CH₂Cl₂ / 3 h / 20 °C

With dmap; potassium hydroxide; tetrapropylammonium perruthennate; 4 A molecular sieve; tetrabutyl ammonium fluoride; tetra-(n-butyl)ammonium iodide; sodium hydride; 4-methylmorpholine N-oxide; triethylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide;
DOI:10.1021/jo0608725

Reference yield:

: 64190-55-2
Benzoic acid (S)-2-((1R,7aR)-7a-methyl-2,3,5,6,7,7a-hexahydro-1H-inden-1-yl)-propyl ester

: 908255-73-2
(1R,3aR,7aR)-1-[(S)-2-(4-Methoxy-benzyloxy)-1-methyl-ethyl]-3a-methoxymethoxy-7a-methyl-octahydro-inden-4-one

Guidance literature:: Multi-step reaction with 8 steps

1: 0.062 g / NaOH / methanol; H₂O / 18 h / 20 °C

2: 74 percent / tetrabutylammonium iodide; NaH / tetrahydrofuran / 18 h / Heating

3: 0.308 g / m-chloroperoxybenzoic acid / CH₂Cl₂ / 2 h / -15 °C

4: 0.192 g / KOH / dimethylsulfoxide; H₂O / 18 h / 140 °C

5: triethylamine / tetrahydrofuran / 4 h / 20 °C

6: 4-(dimethylamino)pyridine; N,N-diisopropylethylamine / CH₂Cl₂ / 72 h / 20 °C

7: 1.17 g / tetrabutylammonium fluoride / tetrahydrofuran / 1 h / 20 °C

8: 98 percent / tetrapropylammonium perruthenate; 4-methylmorpholine N-oxide; molecular sieves 4 Angstroem / CH₂Cl₂ / 3 h / 20 °C

With dmap; potassium hydroxide; sodium hydroxide; tetrapropylammonium perruthennate; 4 A molecular sieve; tetrabutyl ammonium fluoride; tetra-(n-butyl)ammonium iodide; sodium hydride; 4-methylmorpholine N-oxide; triethylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide;
DOI:10.1021/jo0608725