N₁-(2-(dimethylamino)ethyl)-N₁-methyl-N₄-[4-(1-methyl-1H-indol-3-yl)-5-chloropyrimidine-2-yl]-2-nitro 5-methoxybenzene-1,4-diamine

Base Information

• Chemical Name: N₁-(2-(dimethylamino)ethyl)-N₁-methyl-N₄-[4-(1-methyl-1H-indol-3-yl)-5-chloropyrimidine-2-yl]-2-nitro 5-methoxybenzene-1,4-diamine
• CAS No.: 1421372-64-6
• Molecular Formula: C₂₅H₂₈ClN₇O₃
• Molecular Weight: 509.995

Synonyms:N₁-(2-(dimethylamino)ethyl)-N₁-methyl-N₄-[4-(1-methyl-1H-indol-3-yl)-5-chloropyrimidine-2-yl]-2-nitro 5-methoxybenzene-1,4-diamine

Chemical Property of N₁-(2-(dimethylamino)ethyl)-N₁-methyl-N₄-[4-(1-methyl-1H-indol-3-yl)-5-chloropyrimidine-2-yl]-2-nitro 5-methoxybenzene-1,4-diamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N₁-(2-(dimethylamino)ethyl)-N₁-methyl-N₄-[4-(1-methyl-1H-indol-3-yl)-5-chloropyrimidine-2-yl]-2-nitro 5-methoxybenzene-1,4-diamine

There total 6 articles about N₁-(2-(dimethylamino)ethyl)-N₁-methyl-N₄-[4-(1-methyl-1H-indol-3-yl)-5-chloropyrimidine-2-yl]-2-nitro 5-methoxybenzene-1,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

N-(4-fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indol-3-yl)-5-chloropyrimidine-2-amine (1421372-54-4) + N,N',N'-trimethylenediamine (142-25-6) → N1-(2-(dimethylamino)ethyl)-N1-methyl-N4-[4-(1-methyl-1H-indol-3-yl)-5-chloropyrimidine-2-yl]-2-nitro 5-methoxybenzene-1,4-diamine (1421372-64-6)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl acetamide; at 140 ℃; for 0.5h; Microwave irradiation;

Reference yield:

3-(2,5-dichloropyrimidin-4-yl)-1-methyl-1H-indole (1356963-19-3) → N1-(2-(dimethylamino)ethyl)-N1-methyl-N4-[4-(1-methyl-1H-indol-3-yl)-5-chloropyrimidine-2-yl]-2-nitro 5-methoxybenzene-1,4-diamine (1421372-64-6)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / 18 h / 125 °C

2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 0.5 h / 140 °C / Microwave irradiation

With toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl acetamide;

Reference yield:

3-(2,5-dichloropyrimidine-4-yl)-1H-indole (937366-57-9) → N1-(2-(dimethylamino)ethyl)-N1-methyl-N4-[4-(1-methyl-1H-indol-3-yl)-5-chloropyrimidine-2-yl]-2-nitro 5-methoxybenzene-1,4-diamine (1421372-64-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran / 0.42 h / 0 °C / Inert atmosphere

1.2: 2 h / 0 - 20 °C / Inert atmosphere

2.1: toluene-4-sulfonic acid / 18 h / 125 °C

3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 0.5 h / 140 °C / Microwave irradiation

With sodium hydride; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl acetamide;

upstream raw materials:

3-(2,5-dichloropyrimidine-4-yl)-1H-indole

4-fluoro-2-methoxy-5-nitro-phenylamine

N-(4-fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indol-3-yl)-5-chloropyrimidine-2-amine

N,N',N'-trimethylenediamine

Downstream raw materials:

N⁴-[5-chloro-4-(1-methylindol-3-yl)pyrimidin-2-yl]-N¹-(2-dimethylaminoethyl)-5-methoxy-N¹-methylbenzene-1,2,4-triamine

2-{[5-amino-4-(2-dimethylaminoethyl-methylamino)-2-methoxyphenyl]amino}-4-(1-methylindol-3-yl)pyrimidine-5-carbonitrile

N-[5-[[5-chloro-4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]-2-(2-dimethylaminoethylmethylamino)-4-methoxyphenyl]prop-2-enamide

N-[5-[[5-cyano-4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]-2-(2-dimethylaminoethylmethylamino)-4-methoxyphenyl]prop-2-enamide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1421372-64-6 N₁-(2-(dimethylamino)ethyl)-N₁-methyl-N₄-[4-(1-methyl-1H-indol-3-yl)-5-chloropyrimidine-2-yl]-2-nitro 5-methoxybenzene-1,4-diamine

Send

Send

Metric Ton KG G Pound L ML

Send

Send