α-tert-butyl N¹⁰-(trifluoroacetyl)pteroyltriglutamate

Base Information Edit

Chemical Name:α-tert-butyl N¹⁰-(trifluoroacetyl)pteroyltriglutamate
CAS No.:63948-16-3
Molecular Formula:C₄₃H₅₆F₃N₉O₁₃
Molecular Weight:963.965
Hs Code.:
Mol file:63948-16-3.mol

α-tert-butyl N<sup>10</sup>-(trifluoroacetyl)pteroyltriglutamate

Synonyms:α-tert-butyl N¹⁰-(trifluoroacetyl)pteroyltriglutamate

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Chemical Property of α-tert-butyl N¹⁰-(trifluoroacetyl)pteroyltriglutamate Edit

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Technology Process of α-tert-butyl N¹⁰-(trifluoroacetyl)pteroyltriglutamate

There total 4 articles about α-tert-butyl N¹⁰-(trifluoroacetyl)pteroyltriglutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 45120-30-7
L-glutamic acid α-tert-butyl ester

: 63948-16-3
α-tert-butyl N¹⁰-(trifluoroacetyl)pteroyltriglutamate

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / 10percent Na₂CO₃ / dioxane / 20 h / 24 °C

2: dicyclohexylcarbodiimide / CH₂Cl₂ / 0.25 h

3: KH polyamide resin, 4-(dimethylamino)pyridine, N-methylmorpholine, piperidine, 1percent TFA

With piperidine; 4-methyl-morpholine; dmap; KH polyamide resin; sodium carbonate; dicyclohexyl-carbodiimide; trifluoroacetic acid; In 1,4-dioxane; dichloromethane;
DOI:10.1021/jm00164a038

Reference yield:

: 84793-07-7
Fmoc-Glu-OtBu

: 63948-16-3
α-tert-butyl N¹⁰-(trifluoroacetyl)pteroyltriglutamate

Guidance literature:: Multi-step reaction with 2 steps

1: dicyclohexylcarbodiimide / CH₂Cl₂ / 0.25 h

2: KH polyamide resin, 4-(dimethylamino)pyridine, N-methylmorpholine, piperidine, 1percent TFA

With piperidine; 4-methyl-morpholine; dmap; KH polyamide resin; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/jm00164a038

Reference yield:

: 37793-53-6
N¹⁰-(trifluoroacetyl)pteroic acid

: 124126-68-7
α-tert-butyl N-<(9-fluorenylmethoxy)oxy>carbonyl-L-glutamic anhydride

: 63948-16-3
α-tert-butyl N¹⁰-(trifluoroacetyl)pteroyltriglutamate

Guidance literature:: With piperidine; 4-methyl-morpholine; dmap; KH polyamide resin; trifluoroacetic acid; Multistep reaction;
DOI:10.1021/jm00164a038