4-(4-cyano-3,5-dimethyl-phenoxy)-5-cyclopropyl-2H-pyrazole-3-carboxylic acid ethyl ester

Base Information

• Chemical Name: 4-(4-cyano-3,5-dimethyl-phenoxy)-5-cyclopropyl-2H-pyrazole-3-carboxylic acid ethyl ester
• CAS No.: 1079103-87-9
• Molecular Formula: C₁₈H₁₉N₃O₃
• Molecular Weight: 325.367
• Mol file: 1079103-87-9.mol

Synonyms:4-(4-cyano-3,5-dimethyl-phenoxy)-5-cyclopropyl-2H-pyrazole-3-carboxylic acid ethyl ester

Chemical Property of 4-(4-cyano-3,5-dimethyl-phenoxy)-5-cyclopropyl-2H-pyrazole-3-carboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

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Technology Process of 4-(4-cyano-3,5-dimethyl-phenoxy)-5-cyclopropyl-2H-pyrazole-3-carboxylic acid ethyl ester

There total 1 articles about 4-(4-cyano-3,5-dimethyl-phenoxy)-5-cyclopropyl-2H-pyrazole-3-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

ethanol (64-17-5) + 4-(3-cyclopropyl-5-iodo-1H-pyrazol-4-yloxy)-2,6-dimethyl-benzonitrile (1079103-86-8) + carbon monoxide (201230-82-2) → 4-(4-cyano-3,5-dimethyl-phenoxy)-5-cyclopropyl-2H-pyrazole-3-carboxylic acid ethyl ester (1079103-87-9)

Guidance literature:

With palladium diacetate; triethylamine; at 100 ℃; for 16h; under 5171.62 Torr;

DOI:10.1055/s-0029-1219535

Reference yield: 84.0%

chloro-methylsulfanyl-methane (2373-51-5) + 4-(4-cyano-3,5-dimethyl-phenoxy)-5-cyclopropyl-2H-pyrazole-3-carboxylic acid ethyl ester (1079103-87-9) → 4-(4-cyano-3,5-dimethyl-phenoxy)-5-cyclopropyl-2-methylsulfanylmethyl-2H-pyrazole-3-carboxylic acid ethyl ester (1079103-89-1)

Guidance literature:

With 2,6-dimethylpyridine; In 1,2-dimethoxyethane; at 25 ℃; for 16h; regioselective reaction;

DOI:10.1055/s-0029-1219535

Reference yield: 41.0%

chloro-methylsulfanyl-methane (2373-51-5) + 4-(4-cyano-3,5-dimethyl-phenoxy)-5-cyclopropyl-2H-pyrazole-3-carboxylic acid ethyl ester (1079103-87-9) → 4-(4-cyano-3,5-dimethyl-phenoxy)-5-cyclopropyl-2-methylsulfanylmethyl-2H-pyrazole-3-carboxylic acid ethyl ester (1079103-89-1) + 4-(4-cyano-3,5-dimethyl-phenoxy)-5-cyclopropyl-1-methylsulfanylmethyl-1H-pyrazole-3-carboxylic acid ethyl ester (1079103-88-0)

Guidance literature:

4-(4-cyano-3,5-dimethyl-phenoxy)-5-cyclopropyl-2H-pyrazole-3-carboxylic acid ethyl ester; With potassium tert-butylate; In 1,2-dimethoxyethane; at 20 ℃; for 0.166667h;

chloro-methylsulfanyl-methane; In 1,2-dimethoxyethane; at 20 ℃; for 16h;

upstream raw materials:

ethanol

4-(3-cyclopropyl-5-iodo-1H-pyrazol-4-yloxy)-2,6-dimethyl-benzonitrile

carbon monoxide

Downstream raw materials:

4-(4-cyano-3,5-dimethyl-phenoxy)-5-cyclopropyl-2-(2-methoxy-ethyl)-2H-pyrazole-3-carboxylic acid ethyl ester

4-(4-cyano-3,5-dimethyl-phenoxy)-5-cyclopropyl-1-methyl-1H-pyrazole-3-carboxylic acid ethyl ester

4-(4-cyano-3,5-dimethyl-phenoxy)-5-cyclopropyl-2-methyl-2H-pyrazole-3-carboxylic acid ethyl ester

4-(4-cyano-3,5-dimethyl-phenoxy)-5-cyclopropyl-2-ethyl-2H-pyrazole-3-carboxylic acid ethyl ester