2-ethoxycarbonyl-3-(4-methylsilanyl-3-butynyl)cyclohexanone

Base Information

• Chemical Name: 2-ethoxycarbonyl-3-(4-methylsilanyl-3-butynyl)cyclohexanone
• CAS No.: 210366-41-9
• Molecular Formula: C₁₆H₂₆O₃Si
• Molecular Weight: 294.466
• Mol file: 210366-41-9.mol

Synonyms:2-ethoxycarbonyl-3-(4-methylsilanyl-3-butynyl)cyclohexanone

Chemical Property of 2-ethoxycarbonyl-3-(4-methylsilanyl-3-butynyl)cyclohexanone

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 2-ethoxycarbonyl-3-(4-methylsilanyl-3-butynyl)cyclohexanone

There total 3 articles about 2-ethoxycarbonyl-3-(4-methylsilanyl-3-butynyl)cyclohexanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

chloro-trimethyl-silane (75-77-4) + 4-iodo-1-butynyltrimethylsilane (41423-29-4) + ethyl 6-oxocyclohex-1-enecarboxylate (57205-09-1) → 2-ethoxycarbonyl-3-(4-methylsilanyl-3-butynyl)cyclohexanone (210366-41-9)

Guidance literature:

With lithium chloride; zinc; In tetrahydrofuran; at -15 - 40 ℃; for 19h;

DOI:10.1016/S0040-4020(98)00467-0

Reference yield:

ethyl 2-oxocyclohexane carboxylate (1655-07-8) → 2-ethoxycarbonyl-3-(4-methylsilanyl-3-butynyl)cyclohexanone (210366-41-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / pyridine; phenylselenyl chloride / CH₂Cl₂ / 1.5 h / 0 °C

2: 85 percent / Zn; CuCN; LiCl / tetrahydrofuran; various solvent(s) / 19 h / -15 - 40 °C

With pyridine; Phenylselenyl chloride; lithium chloride; zinc; In tetrahydrofuran; dichloromethane; 1: Dehydrogenation / 2: Addition;

DOI:10.1016/S0040-4020(98)00467-0

Reference yield:

ethyl 6-oxocyclohex-1-enecarboxylate (57205-09-1) + ω-trimethylsilylbutynylmagnesium chloride (113893-38-2) → 2-ethoxycarbonyl-3-(4-methylsilanyl-3-butynyl)cyclohexanone (210366-41-9)

Guidance literature:

With chloro-trimethyl-silane; lithium chloride; In tetrahydrofuran;

DOI:10.1055/s-1997-943

upstream raw materials:

ethyl 6-oxocyclohex-1-enecarboxylate

ω-trimethylsilylbutynylmagnesium chloride

chloro-trimethyl-silane

4-iodo-1-butynyltrimethylsilane