4-((3-((4-(piperidin-1-yl)-2-((1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)carbamoyl)phenyl)carbamoyl)benzyl)thio)benzoic acid

Base Information

Chemical Name:4-((3-((4-(piperidin-1-yl)-2-((1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)carbamoyl)phenyl)carbamoyl)benzyl)thio)benzoic acid
CAS No.:1354721-81-5
Molecular Formula:C₃₇H₃₂F₃N₅O₄S
Molecular Weight:699.753
Hs Code.:

Synonyms:4-((3-((4-(piperidin-1-yl)-2-((1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)carbamoyl)phenyl)carbamoyl)benzyl)thio)benzoic acid

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Chemical Property of 4-((3-((4-(piperidin-1-yl)-2-((1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)carbamoyl)phenyl)carbamoyl)benzyl)thio)benzoic acid

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Technology Process of 4-((3-((4-(piperidin-1-yl)-2-((1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)carbamoyl)phenyl)carbamoyl)benzyl)thio)benzoic acid

There total 6 articles about 4-((3-((4-(piperidin-1-yl)-2-((1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)carbamoyl)phenyl)carbamoyl)benzyl)thio)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1074-36-8
4-mercaptobenzoic acid

: 1354722-31-8
2-(3-(chloromethyl)benzamido)-5-(piperidin-1-yl)-N-(1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)benzamide

: 1354721-81-5
4-((3-((4-(piperidin-1-yl)-2-((1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)carbamoyl)phenyl)carbamoyl)benzyl)thio)benzoic acid

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 401-81-0
m-trifluoromethylphenyl iodide

: 1354721-81-5
4-((3-((4-(piperidin-1-yl)-2-((1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)carbamoyl)phenyl)carbamoyl)benzyl)thio)benzoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate; L-proline; copper(l) iodide / dimethyl sulfoxide / 85 °C

2: hydrogen / palladium on activated charcoal / methanol / 20 °C

3: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 50 °C

4: hydrogen / palladium on activated charcoal / ethyl acetate; methanol / 1 h / 20 °C

5: N-ethyl-N,N-diisopropylamine / dichloromethane; tetrahydrofuran / 0 °C

6: potassium carbonate / N,N-dimethyl-formamide / 20 °C

With copper(l) iodide; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; L-proline; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 66000-41-7
1-(3-(trifluoromethyl)phenyl)-3-amino-1H-pyrazole

: 1354721-81-5
4-((3-((4-(piperidin-1-yl)-2-((1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)carbamoyl)phenyl)carbamoyl)benzyl)thio)benzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 50 °C

2: hydrogen / palladium on activated charcoal / ethyl acetate; methanol / 1 h / 20 °C

3: N-ethyl-N,N-diisopropylamine / dichloromethane; tetrahydrofuran / 0 °C

4: potassium carbonate / N,N-dimethyl-formamide / 20 °C

With hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;