1-Methylcyclopentyl phenyl ketone

Base Information

• Chemical Name: 1-Methylcyclopentyl phenyl ketone
• CAS No.: 17206-29-0
• Molecular Formula: C₁₃H₁₆O
• Molecular Weight: 188.269
• Mol file: 17206-29-0.mol

Synonyms:1-Methylcyclopentyl phenyl ketone

Chemical Property of 1-Methylcyclopentyl phenyl ketone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-Methylcyclopentyl phenyl ketone

There total 6 articles about 1-Methylcyclopentyl phenyl ketone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

1,4-dibromo-butane (110-52-1) + 1-phenyl-propan-1-one (93-55-0) → 1-Methylcyclopentyl phenyl ketone (17206-29-0)

Guidance literature:

With potassium tert-butylate; In benzene; for 2.5h; Heating;

DOI:10.1021/jo990634s

Reference yield:

2-chloro-2-methylcyclohexanone (10409-46-8) + phenylmagnesium bromide → 1-Methylcyclopentyl phenyl ketone (17206-29-0) + 2-methyl-2-phenyl-cyclohexanone (17206-54-1)

Guidance literature:

Yield given. Multistep reaction. Yields of byproduct given; 1.) ether, r.t., 2 h; 2.) THF, reflux, 12 h;

Reference yield:

cyclopentanecarboxylic acid (3400-45-1) → 1-Methylcyclopentyl phenyl ketone (17206-29-0)

Guidance literature:

Multi-step reaction with 2 steps

1: (i) SOCl₂, (ii) /BRN= 969212/, AlCl₃

2: (i) NaH, DMSO, (ii) /BRN= 969135/

DOI:10.1021/jo00795a031

upstream raw materials:

2-chloro-2-methylcyclohexanone

phenyl cyclopentyl ketone

methyl iodide

1,4-dibromo-butane

Downstream raw materials:

1-(1-methyl-cyclopentyl)-1-phenyl-prop-2-yn-1-ol

[1,3]dithian-2-yl-(1-methyl-cyclopentyl)-phenyl-methanol

benzaldehyde

Refernces

• 1、 Hori, Mikio,Kataoka, Tadashi,Shimizu, Hiroshi,Imai, Eiji,Iwamura, Tatsunori,Maeda, Kaori. "Ring Contraction of 2-Chlorocyclohexanone with Grignard Reagents". . p. 3599 - 3605. Retrieved 2007/10/02.