{4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-2-methylphenylsulfanyl}acetic acid tert-butyl ester

Base Information

Chemical Name:{4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-2-methylphenylsulfanyl}acetic acid tert-butyl ester
CAS No.:1413285-53-6
Molecular Formula:C₂₃H₂₂Cl₂F₃NO₃S
Molecular Weight:520.4
Hs Code.:

Synonyms:{4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-2-methylphenylsulfanyl}acetic acid tert-butyl ester

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Chemical Property of {4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-2-methylphenylsulfanyl}acetic acid tert-butyl ester

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Technology Process of {4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-2-methylphenylsulfanyl}acetic acid tert-butyl ester

There total 3 articles about {4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-2-methylphenylsulfanyl}acetic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5-(3,5-dichloro-phenyl)-3-(4-bromo-3-methyl-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazole

: 20291-99-0
t-butyl mercaptoacetate

: 1413285-53-6
{4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-2-methylphenylsulfanyl}acetic acid tert-butyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; at 120 ℃; for 0.5h; Microwave irradiation;

Reference yield:

: 180082-96-6
4-bromo-3-methylbenzaldehyde oxime

: 1413285-53-6
{4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-2-methylphenylsulfanyl}acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-chloro-succinimide / N,N-dimethyl-formamide / 2 h / 20 °C

1.2: 28 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 0.5 h / 120 °C / Microwave irradiation

With N-chloro-succinimide; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; N,N-dimethyl-formamide;

Reference yield:

: 78775-11-8
3-methyl-4-bromobenzaldehyde

: 1413285-53-6
{4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-2-methylphenylsulfanyl}acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydroxylamine hydrochloride; sodium acetate / ethanol; water / 0.17 h / 20 °C

2.1: N-chloro-succinimide / N,N-dimethyl-formamide / 2 h / 20 °C

2.2: 28 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 0.5 h / 120 °C / Microwave irradiation

With N-chloro-succinimide; hydroxylamine hydrochloride; sodium acetate; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide;