N-(5-Formyl-8-pyridin-3-yl-octyl)-4-methanesulfonyl-benzenesulfonamide

Base Information

Chemical Name:N-(5-Formyl-8-pyridin-3-yl-octyl)-4-methanesulfonyl-benzenesulfonamide
CAS No.:1026735-52-3
Molecular Formula:C₂₁H₂₈N₂O₅S₂
Molecular Weight:452.596
Hs Code.:

Synonyms:N-(5-Formyl-8-pyridin-3-yl-octyl)-4-methanesulfonyl-benzenesulfonamide

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Chemical Property of N-(5-Formyl-8-pyridin-3-yl-octyl)-4-methanesulfonyl-benzenesulfonamide

Chemical Property:

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Technology Process of N-(5-Formyl-8-pyridin-3-yl-octyl)-4-methanesulfonyl-benzenesulfonamide

There total 8 articles about N-(5-Formyl-8-pyridin-3-yl-octyl)-4-methanesulfonyl-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1027416-24-5
6-(4-Methanesulfonyl-benzenesulfonylamino)-2-(3-pyridin-3-yl-propyl)-hexanoic acid ethyl ester

: 1026735-52-3
N-(5-Formyl-8-pyridin-3-yl-octyl)-4-methanesulfonyl-benzenesulfonamide

Guidance literature:: With diisobutylaluminium hydride; In dichloromethane; toluene; at -78 ℃; for 0.0833333h;
DOI:10.1021/jm00101a015

Reference yield:

: 41038-63-5
3-(pyridin-3-yl)propyl bromide hydrobromide

: 1026735-52-3
N-(5-Formyl-8-pyridin-3-yl-octyl)-4-methanesulfonyl-benzenesulfonamide

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) Na / 1.) EtOH, 2.) EtOH, reflux, 10 h

2: 1.) NaH / 1.) DMF, 30 min, 2.) DMF, 60 deg C, 10 h

3: NaN₃, NaI, 18-crown-6 / dimethylformamide / 18 h / 60 °C

4: Ph₃P, H₂O / tetrahydrofuran / 62 h / Ambient temperature

5: 6N HCl / acetic acid / 18 h / Heating

6: SOCl₂ / 18 h / Heating

7: Et₃N / CH₂Cl₂ / 18 h

8: diisobutylaluminum hydride / CH₂Cl₂; toluene / 0.08 h / -78 °C

With hydrogenchloride; thionyl chloride; sodium azide; 18-crown-6 ether; water; sodium; sodium hydride; diisobutylaluminium hydride; triethylamine; triphenylphosphine; sodium iodide; In tetrahydrofuran; dichloromethane; acetic acid; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00101a015

Reference yield:

: 144385-78-4
6-Amino-2-(3-pyridin-3-yl-propyl)-hexanoic acid

: 1026735-52-3
N-(5-Formyl-8-pyridin-3-yl-octyl)-4-methanesulfonyl-benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: SOCl₂ / 18 h / Heating

2: Et₃N / CH₂Cl₂ / 18 h

3: diisobutylaluminum hydride / CH₂Cl₂; toluene / 0.08 h / -78 °C

With thionyl chloride; diisobutylaluminium hydride; triethylamine; In dichloromethane; toluene;
DOI:10.1021/jm00101a015