(2E)-3-(4-methoxy-2-methylphenyl)-2-propenoic acid

Base Information

• Chemical Name: (2E)-3-(4-methoxy-2-methylphenyl)-2-propenoic acid
• CAS No.: 100606-34-6
• Molecular Formula: C₁₁H₁₂O₃
• Molecular Weight: 192.214
• Mol file: 100606-34-6.mol

Synonyms:(2E)-3-(4-methoxy-2-methylphenyl)-2-propenoic acid

Chemical Property of (2E)-3-(4-methoxy-2-methylphenyl)-2-propenoic acid

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

(E)-3-(4-methoxy-2-methylphenyl)acrylicacid 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2E)-3-(4-methoxy-2-methylphenyl)-2-propenoic acid

There total 4 articles about (2E)-3-(4-methoxy-2-methylphenyl)-2-propenoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(E)-3-(4-methoxy-2-methylphenyl)acrylic acid tert-butyl ester (174810-40-3) → (2E)-3-(4-methoxy-2-methylphenyl)-2-propenoic acid (100606-34-6)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 23 ℃; for 5h;

DOI:10.1021/ja012487x

Reference yield: 91.0%

malonic acid (141-82-2) + 4-methoxysalicylaldehyde (52289-54-0) → (2E)-3-(4-methoxy-2-methylphenyl)-2-propenoic acid (100606-34-6)

Guidance literature:

With piperidine; In pyridine; at 100 ℃; for 17h;

Reference yield:

4-bromo-3-methylanisole (27060-75-9) → (2E)-3-(4-methoxy-2-methylphenyl)-2-propenoic acid (100606-34-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / triethylamine; tri-o-tolylphosphine; palladium diacetate / 12 h / 108 °C

2: 100 percent / trifluoroacetic acid / CH₂Cl₂ / 5 h / 23 °C

With palladium diacetate; triethylamine; tris-(o-tolyl)phosphine; trifluoroacetic acid; In dichloromethane;

DOI:10.1021/ja012487x

upstream raw materials:

malonic acid

4-methoxysalicylaldehyde

(E)-3-(4-methoxy-2-methylphenyl)acrylic acid tert-butyl ester

4-bromo-3-methylanisole

Downstream raw materials:

(3(3R),4S)-4-phenyl-3-<3-(4'-methoxy-2'-methylphenyl)butanoyl>-2-oxazolidinone

2-chloro-3-hydroxy-5-(4-methoxy-2-methylphenyl)penta-2,4-dienoic acid methyl ester

5-(4-methoxy-2-methylphenyl)-3-oxopent-4-enoic acid methyl ester

ethyl (E)-3-(4-methoxy-2-methylphenyl)-2-propenoate