(R)-5-(2-phenylsulphonylethenyl)-3-(N-methylpyrrolidine-2-yl-methyl)-1H-indole formate

Base Information

Chemical Name:(R)-5-(2-phenylsulphonylethenyl)-3-(N-methylpyrrolidine-2-yl-methyl)-1H-indole formate
CAS No.:1196663-27-0
Molecular Formula:CH₂O₂*C₂₂H₂₄N₂O₂S
Molecular Weight:426.536
Hs Code.:

Synonyms:(R)-5-(2-phenylsulphonylethenyl)-3-(N-methylpyrrolidine-2-yl-methyl)-1H-indole formate

Suppliers and Price of (R)-5-(2-phenylsulphonylethenyl)-3-(N-methylpyrrolidine-2-yl-methyl)-1H-indole formate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-5-(2-phenylsulphonylethenyl)-3-(N-methylpyrrolidine-2-yl-methyl)-1H-indole formate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (R)-5-(2-phenylsulphonylethenyl)-3-(N-methylpyrrolidine-2-yl-methyl)-1H-indole formate

There total 4 articles about (R)-5-(2-phenylsulphonylethenyl)-3-(N-methylpyrrolidine-2-yl-methyl)-1H-indole formate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 64-18-6
formic acid

: 180637-89-2
(R)-5-[(2-phenylsulfonyl)ethenyl]-3-(N-methylpyrrolidine-2-ylmethyl)-1H-indole

: 16712-16-6,64165-14-6,65387-22-6,70179-79-2,540-69-2
ammonium formate

: 1196663-27-0
(R)-5-(2-phenylsulphonylethenyl)-3-(N-methylpyrrolidine-2-yl-methyl)-1H-indole formate

Guidance literature:: In acetonitrile; at 30 - 40 ℃;

Reference yield:

: 64-18-6
formic acid

: 180637-88-1
(R)-1-acetyl-5-[2-(phenylsulfonyl)ethyenyl]-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole

: 1196663-27-0
(R)-5-(2-phenylsulphonylethenyl)-3-(N-methylpyrrolidine-2-yl-methyl)-1H-indole formate

Guidance literature:: (R)-1-acetyl-5-[2-(phenylsulfonyl)ethyenyl]-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole; With methanol; potassium carbonate;

formic acid; In ethyl acetate; acetone; at 25 - 30 ℃;

Reference yield:

: C₁₆H₁₉BrN₂O

: 1196663-27-0
(R)-5-(2-phenylsulphonylethenyl)-3-(N-methylpyrrolidine-2-yl-methyl)-1H-indole formate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / palladium diacetate; tris-(o-tolyl)phosphine / acetonitrile / 25 - 35 °C

1.2: 25 - 83 °C

2.1: potassium carbonate; methanol

2.2: 25 - 30 °C

With methanol; potassium carbonate; triethylamine; palladium diacetate; tris-(o-tolyl)phosphine; In acetonitrile;