(S)-3-(4-{2-amino-6-[1-(4-bromo-2-fluorophenyl)-2,2,2-trifluoroethoxy]pyrimidine-4-yl}phenyl)-2-tert-butoxycarbonylaminopropionic acid

Base Information

Chemical Name:(S)-3-(4-{2-amino-6-[1-(4-bromo-2-fluorophenyl)-2,2,2-trifluoroethoxy]pyrimidine-4-yl}phenyl)-2-tert-butoxycarbonylaminopropionic acid
CAS No.:1033805-89-8
Molecular Formula:C₂₆H₂₅BrF₄N₄O₅
Molecular Weight:629.406
Hs Code.:

Synonyms:(S)-3-(4-{2-amino-6-[1-(4-bromo-2-fluorophenyl)-2,2,2-trifluoroethoxy]pyrimidine-4-yl}phenyl)-2-tert-butoxycarbonylaminopropionic acid

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Chemical Property of (S)-3-(4-{2-amino-6-[1-(4-bromo-2-fluorophenyl)-2,2,2-trifluoroethoxy]pyrimidine-4-yl}phenyl)-2-tert-butoxycarbonylaminopropionic acid

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Technology Process of (S)-3-(4-{2-amino-6-[1-(4-bromo-2-fluorophenyl)-2,2,2-trifluoroethoxy]pyrimidine-4-yl}phenyl)-2-tert-butoxycarbonylaminopropionic acid

There total 2 articles about (S)-3-(4-{2-amino-6-[1-(4-bromo-2-fluorophenyl)-2,2,2-trifluoroethoxy]pyrimidine-4-yl}phenyl)-2-tert-butoxycarbonylaminopropionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1033805-88-7
1-(4-bromo-2-fluorophenyl)-2,2,2-trifluoroethanol

: 1033804-86-2
(S)-3-[4-(2-amino-6-chloropyrimidin-4-yl)phenyl]-2-{[(tert-butoxy)carbonyl]amino}propanoic acid

: 1033805-89-8
(S)-3-(4-{2-amino-6-[1-(4-bromo-2-fluorophenyl)-2,2,2-trifluoroethoxy]pyrimidine-4-yl}phenyl)-2-tert-butoxycarbonylaminopropionic acid

Guidance literature:: 1-(4-bromo-2-fluorophenyl)-2,2,2-trifluoroethanol; With caesium carbonate; In 1,4-dioxane; for 0.0833333h;

(S)-3-[4-(2-amino-6-chloropyrimidin-4-yl)phenyl]-2-{[(tert-butoxy)carbonyl]amino}propanoic acid; In 1,4-dioxane; at 110 ℃;

Reference yield:

: 57848-46-1
4-bromo-2-fluorobenzaldehyde

: 1033805-89-8
(S)-3-(4-{2-amino-6-[1-(4-bromo-2-fluorophenyl)-2,2,2-trifluoroethoxy]pyrimidine-4-yl}phenyl)-2-tert-butoxycarbonylaminopropionic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / 0 - 20 °C

2.1: caesium carbonate / 1,4-dioxane / 0.08 h

2.2: 110 °C

With tetrabutyl ammonium fluoride; caesium carbonate; In tetrahydrofuran; 1,4-dioxane;

Reference yield:

: 445264-60-8
3-methoxy-5-pyridineboronic acid pinacol ester

: 1033805-89-8
(S)-3-(4-{2-amino-6-[1-(4-bromo-2-fluorophenyl)-2,2,2-trifluoroethoxy]pyrimidine-4-yl}phenyl)-2-tert-butoxycarbonylaminopropionic acid

: 1033805-90-1
(S)-3-[4-(2-amino-6-{2,2,2trifluoro-1-[2-fluoro-4-(5-methoxypyridin-3-yl)phenyl]ethoxy}pyrimidin-4-yl)phenyl]-2-tert-butoxycarbonylaminopropionic acid

Guidance literature:: With sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In water; acetonitrile; at 150 ℃; for 0.0833333h; Microwave irradiation;