1-(4-broMo-2-fluorophenyl)-2,2,2-trifluoroethanol

Base Information

• Chemical Name: 1-(4-broMo-2-fluorophenyl)-2,2,2-trifluoroethanol
• CAS No.: 1033805-88-7
• Molecular Formula: C8H5BrF4O
• Molecular Weight: 273.025
• Mol file: 1033805-88-7.mol

Synonyms:1-(4-broMo-2-fluorophenyl)-2,2,2-trifluoroethanol;1-(4-Bromo-2-fluorophenyl)-2,2,2-trifluoroethan-1-ol

Chemical Property of 1-(4-broMo-2-fluorophenyl)-2,2,2-trifluoroethanol

Chemical Property:

• PSA: 20.23000
• LogP: 3.18390
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

1-(4-Bromo-2-fluorophenyl)-2,2,2-trifluoroethan-1-ol 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(4-broMo-2-fluorophenyl)-2,2,2-trifluoroethanol

There total 1 articles about 1-(4-broMo-2-fluorophenyl)-2,2,2-trifluoroethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(trifluoromethyl)trimethylsilane (81290-20-2) + 4-bromo-2-fluorobenzaldehyde (57848-46-1) → 1-(4-bromo-2-fluorophenyl)-2,2,2-trifluoroethanol (1033805-88-7)

Guidance literature:

(trifluoromethyl)trimethylsilane; 4-bromo-2-fluorobenzaldehyde; With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 - 20 ℃; for 3.16667h; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; water; Inert atmosphere;

Reference yield: 95.0%

1-(4-bromo-2-fluorophenyl)-2,2,2-trifluoroethanol (1033805-88-7) → 1-(4-bromo-2-fluorophenyl)-2,2,2-trifluoroethan-1-one (617706-18-0)

Guidance literature:

With 2-iodoxybenzoic acid; In ethyl acetate; Reflux;

Reference yield: 82.0%

1-(4-bromo-2-fluorophenyl)-2,2,2-trifluoroethanol (1033805-88-7) + (S)-3-[4-(2-amino-6-chloropyrimidin-4-yl)phenyl]-2-{[(tert-butoxy)carbonyl]amino}propanoic acid (1033804-86-2) → (S)-3-(4-{2-amino-6-[1-(4-bromo-2-fluorophenyl)-2,2,2-trifluoroethoxy]pyrimidine-4-yl}phenyl)-2-tert-butoxycarbonylaminopropionic acid (1033805-89-8)

Guidance literature:

1-(4-bromo-2-fluorophenyl)-2,2,2-trifluoroethanol; With caesium carbonate; In 1,4-dioxane; for 0.0833333h;

(S)-3-[4-(2-amino-6-chloropyrimidin-4-yl)phenyl]-2-{[(tert-butoxy)carbonyl]amino}propanoic acid; In 1,4-dioxane; at 110 ℃;

upstream raw materials:

(trifluoromethyl)trimethylsilane

4-bromo-2-fluorobenzaldehyde

Downstream raw materials:

(S)-3-(4-{2-amino-6-[1-(4-bromo-2-fluorophenyl)-2,2,2-trifluoroethoxy]pyrimidine-4-yl}phenyl)-2-tert-butoxycarbonylaminopropionic acid

1-(4-bromo-2-fluorophenyl)-2,2,2-trifluoroethan-1-one

6-bromo-3-(trifluoromethyl)-1H-indazole

(S)-2-amino-3-[4-(2-amino-6-{2,2,2-trifluoro-1-[2-fluoro-4-(5-methoxy-pyridin-3-yl)-phenyl]-ethoxy}-pyrimidin-4-yl)-phenyl]-propionic acid

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