amantadine-5-chloro-salicylaldehyde

Base Information

• Chemical Name: amantadine-5-chloro-salicylaldehyde
• CAS No.: 532420-46-5
• Molecular Formula: C₁₇H₂₀ClNO
• Molecular Weight: 289.805
• Mol file: 532420-46-5.mol

Synonyms:amantadine-5-chloro-salicylaldehyde

Chemical Property of amantadine-5-chloro-salicylaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of amantadine-5-chloro-salicylaldehyde

There total 2 articles about amantadine-5-chloro-salicylaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

1-Adamantanamine (768-94-5) + 5-chlorosalicyclaldehyde (635-93-8) → amantadine-5-chloro-salicylaldehyde (532420-46-5)

Guidance literature:

In ethanol; for 1h; Reflux;

DOI:10.1134/S1070328417110033

Reference yield:

amantadine hydrochloride (665-66-7,13878-11-0) + 5-chlorosalicyclaldehyde (635-93-8) → amantadine-5-chloro-salicylaldehyde (532420-46-5)

Guidance literature:

amantadine hydrochloride; With potassium hydroxide; In ethanol; for 24h;

5-chlorosalicyclaldehyde; In ethanol; at 95 ℃; for 3h;

DOI:10.1016/j.saa.2011.08.076

upstream raw materials:

amantadine hydrochloride

5-chlorosalicyclaldehyde

1-Adamantanamine