Technology Process of 2-<3,5-bis(trifluoromethyl)phenyl>propan-1-ol
There total 5 articles about 2-<3,5-bis(trifluoromethyl)phenyl>propan-1-ol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
(1,4-dimethyl-5,7-diphenyl-1,2,3,4-tetrahydro-6H-cyclopenta[b]pyrazin-6-one) irontricarbonyl complex3; sodium hydroxide; sodium t-butanolate;
In
tert-butyl alcohol;
at 110 ℃;
for 40h;
Schlenk technique;
Inert atmosphere;
DOI:10.1021/acs.orglett.9b03171
- Guidance literature:
-
Multi-step reaction with 2 steps
1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere; Schlenk technique; Reflux
2: (1,4-dimethyl-5,7-diphenyl-1,2,3,4-tetrahydro-6H-cyclopenta[b]pyrazin-6-one) irontricarbonyl complex3; sodium hydroxide; sodium t-butanolate / tert-butyl alcohol / 40 h / 110 °C / Schlenk technique; Inert atmosphere
With
lithium aluminium tetrahydride; (1,4-dimethyl-5,7-diphenyl-1,2,3,4-tetrahydro-6H-cyclopenta[b]pyrazin-6-one) irontricarbonyl complex3; sodium hydroxide; sodium t-butanolate;
In
tetrahydrofuran; tert-butyl alcohol;
DOI:10.1021/acs.orglett.9b03171
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 95.1 percent / Mg / diethyl ether / 0.5 h / Ambient temperature
2: 81.5 percent / hexamethylphosphoric triamide / 1.5 h / 240 °C
3: 1.) BH3-THF, 2.) 30percent H2O2, 10percent aq. NaOH / 1.) THF, RT, 2 h, 2.) THF, reflux, 1 h
With
N,N,N,N,N,N-hexamethylphosphoric triamide; sodium hydroxide; borane-THF; dihydrogen peroxide; magnesium;
In
diethyl ether;
