1,3-Dihydro-5-methoxy-3-methyl-2h-indol-2-one

Base Information

Chemical Name:1,3-Dihydro-5-methoxy-3-methyl-2h-indol-2-one
CAS No.:101349-16-0
Molecular Formula:C₁₀H₁₁NO₂
Molecular Weight:177.203
Hs Code.:
DSSTox Substance ID:DTXSID101252673

Synonyms:1,3-dihydro-5-methoxy-3-methyl-2h-indol-2-one;101349-16-0;SCHEMBL15730582;DTXSID101252673

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1,3-Dihydro-5-methoxy-3-methyl-2h-indol-2-one

Chemical Property:

XLogP3:1.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:177.078978594
Heavy Atom Count:13
Complexity:217

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1C2=C(C=CC(=C2)OC)NC1=O

Technology Process of 1,3-Dihydro-5-methoxy-3-methyl-2h-indol-2-one

There total 4 articles about 1,3-Dihydro-5-methoxy-3-methyl-2h-indol-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 7699-18-5
5-methoxyindolin-2-one

: 101349-16-0
5-methoxy-3-methyl-2-indolinone

Guidance literature:: 5-methoxyindolin-2-one; With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h; Inert atmosphere;

methyl halide; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 3h; Inert atmosphere;
DOI:10.1002/chem.201700851

Reference yield: 65.0%

: 7699-18-5
5-methoxyindolin-2-one

: 74-88-4
methyl iodide

: 101349-16-0
5-methoxy-3-methyl-2-indolinone

Guidance literature:: 5-methoxyindolin-2-one; With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; at -78 ℃; for 0.5h;

methyl iodide; at -78 ℃; for 2h;
DOI:10.1016/j.bmcl.2017.08.005

Reference yield:

: 1536478-38-2
N-(4-methoxy-2-vinylphenyl)formamide

: 54197-64-7
6-methoxy-2-oxo-1,2,3,4-tetrahydroquinoline

: 101349-16-0
5-methoxy-3-methyl-2-indolinone

Guidance literature:: With dodecacarbonyl-triangulo-triruthenium; tetra-(n-butyl)ammonium iodide; In dimethyl sulfoxide; toluene; at 20 - 120 ℃; for 6.08h; Overall yield = 79 %; regioselective reaction; Sealed tube;
DOI:10.1021/ja411913e