[phenyl-(toluene-4-sulfonyl)-methyl]-carbamic acid benzyl ester

Base Information

• Chemical Name: [phenyl-(toluene-4-sulfonyl)-methyl]-carbamic acid benzyl ester
• CAS No.: 372199-85-4
• Molecular Formula: C₂₂H₂₁NO₄S
• Molecular Weight: 395.479
• Mol file: 372199-85-4.mol

Synonyms:[phenyl-(toluene-4-sulfonyl)-methyl]-carbamic acid benzyl ester

Chemical Property of [phenyl-(toluene-4-sulfonyl)-methyl]-carbamic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of [phenyl-(toluene-4-sulfonyl)-methyl]-carbamic acid benzyl ester

There total 4 articles about [phenyl-(toluene-4-sulfonyl)-methyl]-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

O-benzyl carbamate (621-84-1) + benzaldehyde (100-52-7) + sodium 4-methylbenzenesulfinate (824-79-3) → [phenyl-(toluene-4-sulfonyl)-methyl]-carbamic acid benzyl ester (372199-85-4)

Guidance literature:

With formic acid; In water; for 18h; Reflux;

DOI:10.2174/1570178614666170811121704

Reference yield: 75.0%

[1-(N-benzyloxycarbonylamino)-1-phenylmethyl]triphenylphosphonium tetrafluoroborate + sodium 4-methylbenzenesulfinate (824-79-3) → [phenyl-(toluene-4-sulfonyl)-methyl]-carbamic acid benzyl ester (372199-85-4)

Guidance literature:

In chloroform; at 20 ℃; for 2h;

DOI:10.1021/jo500174a

Reference yield:

2-(benzyloxycarbonylamino)-2-phenylacetic acid (5491-18-9) → [phenyl-(toluene-4-sulfonyl)-methyl]-carbamic acid benzyl ester (372199-85-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 3-(1-piperidino)propylfunctionalized silica gel / 10 °C / Electrolysis

2: chloroform / 20 °C

3: chloroform / 2 h / 20 °C

With 3-(1-piperidino)propylfunctionalized silica gel; In chloroform;

DOI:10.1021/jo500174a

upstream raw materials:

O-benzyl carbamate

benzaldehyde

sodium 4-methylbenzenesulfinate

2-(benzyloxycarbonylamino)-2-phenylacetic acid

Downstream raw materials:

O,O-diphenyl {[(benzyloxy)carbonyl]amino}(phenyl)methylphosphonate

O,O-dimethyl {[(benzyloxy)carbonyl]amino}(phenyl)methylphosphonate

1-methyl-1-(2-methyl-1H-3-indolyl)ethyl (4-methylphenyl)sulfone

C₂₃H₂₁NO₂S