(S)-2-(benzyloxycarbonylaminophenylmethyl)malonic acid bis(4-methoxyphenyl) ester

Base Information

• Chemical Name: (S)-2-(benzyloxycarbonylaminophenylmethyl)malonic acid bis(4-methoxyphenyl) ester
• CAS No.: 948853-03-0
• Molecular Formula: C₃₂H₂₉NO₈
• Molecular Weight: 555.584
• Mol file: 948853-03-0.mol

Synonyms:(S)-2-(benzyloxycarbonylaminophenylmethyl)malonic acid bis(4-methoxyphenyl) ester

Chemical Property of (S)-2-(benzyloxycarbonylaminophenylmethyl)malonic acid bis(4-methoxyphenyl) ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of (S)-2-(benzyloxycarbonylaminophenylmethyl)malonic acid bis(4-methoxyphenyl) ester

There total 2 articles about (S)-2-(benzyloxycarbonylaminophenylmethyl)malonic acid bis(4-methoxyphenyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

malonic acid bis(4-methoxyphenyl) ester (926913-48-6) + [phenyl-(toluene-4-sulfonyl)-methyl]-carbamic acid benzyl ester (372199-85-4) → (S)-2-(benzyloxycarbonylaminophenylmethyl)malonic acid bis(4-methoxyphenyl) ester (948853-03-0)

Guidance literature:

With potassium carbonate; N-(2-methoxybenzyl)-quininium chloride; In toluene; at -24 ℃; for 60h;

DOI:10.1002/chem.200700908

Reference yield:

4-methoxy-phenol (150-76-5) → (S)-2-(benzyloxycarbonylaminophenylmethyl)malonic acid bis(4-methoxyphenyl) ester (948853-03-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / POCl₃ / 2 h / 115 °C

2: 81 percent / aq. K₂CO₃; N-(o-cyanobenzyl)quininium bromide / toluene / 48 h / -20 °C

With N-(o-cyanobenzyl)quininium bromide; potassium carbonate; trichlorophosphate; In toluene; 2: Mannich reaction;

DOI:10.1002/adsc.200600250

Reference yield: 91.0%

(S)-2-(benzyloxycarbonylaminophenylmethyl)malonic acid bis(4-methoxyphenyl) ester (948853-03-0) + methanol (67-56-1) → 2-(benzyloxycarbonylamino-phenyl-methyl)-malonic acid dimethyl ester

Guidance literature:

With potassium hydroxide; at 20 ℃; for 0.5h;

DOI:10.1002/adsc.200600250

upstream raw materials:

malonic acid bis(4-methoxyphenyl) ester

[phenyl-(toluene-4-sulfonyl)-methyl]-carbamic acid benzyl ester

4-methoxy-phenol