1-13C-2,2-diphenylacetaldehyde

Base Information

• Chemical Name: 1-13C-2,2-diphenylacetaldehyde
• CAS No.: 409149-73-1
• Molecular Formula: C₁₄H₁₂O
• Molecular Weight: 197.238
• Mol file: 409149-73-1.mol

Synonyms:1-13C-2,2-diphenylacetaldehyde

Chemical Property of 1-13C-2,2-diphenylacetaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-13C-2,2-diphenylacetaldehyde

There total 3 articles about 1-13C-2,2-diphenylacetaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

1-13C-2,2-diphenylethanol (409149-67-3) → 1-13C-2,2-diphenylacetaldehyde (409149-73-1)

Guidance literature:

With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane; at -70 ℃; for 0.333333h;

DOI:10.1021/ja0124562

Reference yield:

benzophenone (119-61-9) → 1-13C-2,2-diphenylacetaldehyde (409149-73-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: NaH; DMSO / 0.5 h / 20 °C

1.2: 76 percent / dimethylsulfoxide / 24 h / 20 °C

2.1: BH₃*THF / tetrahydrofuran / 4 h / 20 °C

2.2: 74 percent / 30percent H₂O₂; 3.0 M aq. NaOH / tetrahydrofuran / 1.5 h / 20 °C

3.1: 76 percent / (COCl)2; DMSO; Et₃N / CH₂Cl₂ / 0.33 h / -70 °C

With borane-THF; oxalyl dichloride; sodium hydride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; dichloromethane; 1.2: Wittig reaction / 3.1: Swern oxidation;

DOI:10.1021/ja0124562

Reference yield:

2-13C-1,1-diphenylethylene (409149-61-7) → 1-13C-2,2-diphenylacetaldehyde (409149-73-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: BH₃*THF / tetrahydrofuran / 4 h / 20 °C

1.2: 74 percent / 30percent H₂O₂; 3.0 M aq. NaOH / tetrahydrofuran / 1.5 h / 20 °C

2.1: 76 percent / (COCl)2; DMSO; Et₃N / CH₂Cl₂ / 0.33 h / -70 °C

With borane-THF; oxalyl dichloride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; dichloromethane; 2.1: Swern oxidation;

DOI:10.1021/ja0124562

upstream raw materials:

1-13C-2,2-diphenylethanol

benzophenone

2-13C-1,1-diphenylethylene

Downstream raw materials:

3-13C-2-methyl-4,4-diphenylcyclohex-2-enone