N-Fmoc-(2S)-alanyl-aza-phenylalanyl-(2S)-prolyl-tert-butyl ester

Base Information

• Chemical Name: N-Fmoc-(2S)-alanyl-aza-phenylalanyl-(2S)-prolyl-tert-butyl ester
• CAS No.: 1234782-79-6
• Molecular Formula: C₃₅H₄₀N₄O₆
• Molecular Weight: 612.726
• Mol file: 1234782-79-6.mol

Synonyms:N-Fmoc-(2S)-alanyl-aza-phenylalanyl-(2S)-prolyl-tert-butyl ester

Chemical Property of N-Fmoc-(2S)-alanyl-aza-phenylalanyl-(2S)-prolyl-tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-Fmoc-(2S)-alanyl-aza-phenylalanyl-(2S)-prolyl-tert-butyl ester

There total 5 articles about N-Fmoc-(2S)-alanyl-aza-phenylalanyl-(2S)-prolyl-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

aza-phenylalaninyl-proline tert-butyl ester (84766-98-3) + Fmoc-Ala-OCO2i-Bu → N-Fmoc-(2S)-alanyl-aza-phenylalanyl-(2S)-prolyl-tert-butyl ester (1234782-79-6)

Guidance literature:

In tetrahydrofuran; at -15 ℃; for 1h;

DOI:10.1002/psc.1235

Reference yield:

aza-phenylalaninyl-proline tert-butyl ester (84766-98-3) + N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine (35661-39-3,136132-75-7) → N-Fmoc-(2S)-alanyl-aza-phenylalanyl-(2S)-prolyl-tert-butyl ester (1234782-79-6)

Guidance literature:

With 4-methyl-morpholine; isobutyl chloroformate; In tetrahydrofuran; ethyl acetate; at -15 ℃; for 1h; Inert atmosphere;

DOI:10.1016/j.bmcl.2014.05.095

Reference yield:

benzhydrylidene aza-glycinyl-proline tert-butyl ester (1234783-06-2) → N-Fmoc-(2S)-alanyl-aza-phenylalanyl-(2S)-prolyl-tert-butyl ester (1234782-79-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium tert-butylate / tetrahydrofuran / 0.25 h / 0 °C / Inert atmosphere

1.2: 0 - 20 °C / Inert atmosphere

2.1: pyridine; hydroxylamine hydrochloride / 12 h / 60 °C / Inert atmosphere

3.1: tetrahydrofuran / 1 h / -15 °C

With pyridine; hydroxylamine hydrochloride; potassium tert-butylate; In tetrahydrofuran;

DOI:10.1002/psc.1235

upstream raw materials:

benzhydrylidene aza-glycinyl-proline tert-butyl ester

benzhydrylidene aza-phenylalaninyl-proline tert-butyl ester

aza-phenylalaninyl-proline tert-butyl ester

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

Downstream raw materials:

(2S)-alanyl-aza-phenylalanyl-(2S)-prolyl-diphenylmethyl amide

N-Fmoc-(2S)-alanyl-aza-phenylalanyl-(2S)-prolyl-diphenylmethyl amide