Technology Process of N-Fmoc-(2S)-alanyl-aza-phenylalanyl-(2S)-prolyl-diphenylmethyl amide
There total 5 articles about N-Fmoc-(2S)-alanyl-aza-phenylalanyl-(2S)-prolyl-diphenylmethyl amide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
4-methyl-morpholine; isobutyl chloroformate;
In
tetrahydrofuran;
at -15 ℃;
for 1h;
Inert atmosphere;
DOI:10.1016/j.bmcl.2014.05.095
- Guidance literature:
-
Multi-step reaction with 5 steps
1: potassium tert-butylate / tetrahydrofuran / -15 °C / Inert atmosphere
2: hydroxylamine hydrochloride; pyridine / 12 h / 60 °C / Inert atmosphere
3: isobutyl chloroformate; 4-methyl-morpholine / tetrahydrofuran; ethyl acetate / 1 h / -15 °C / Inert atmosphere
4: trifluoroacetic acid / dichloromethane / 1 h / 20 °C / Inert atmosphere
5: isobutyl chloroformate; 4-methyl-morpholine / tetrahydrofuran / 1 h / -15 °C / Inert atmosphere
With
4-methyl-morpholine; pyridine; hydroxylamine hydrochloride; potassium tert-butylate; trifluoroacetic acid; isobutyl chloroformate;
In
tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1016/j.bmcl.2014.05.095
- Guidance literature:
-
Multi-step reaction with 3 steps
1: isobutyl chloroformate; 4-methyl-morpholine / tetrahydrofuran; ethyl acetate / 1 h / -15 °C / Inert atmosphere
2: trifluoroacetic acid / dichloromethane / 1 h / 20 °C / Inert atmosphere
3: isobutyl chloroformate; 4-methyl-morpholine / tetrahydrofuran / 1 h / -15 °C / Inert atmosphere
With
4-methyl-morpholine; trifluoroacetic acid; isobutyl chloroformate;
In
tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1016/j.bmcl.2014.05.095
