4,5-dihydro-2-[4-[[[[2-[[(4-methoxy-2,6-dimethylphenyl)sulfonyl]methylamino]ethoxy]acetyl]methylamino]methyl]phenyl]-1H-imidazole-1-carboxylic acid 1,1-dimethylethyl ester

Base Information

Chemical Name:4,5-dihydro-2-[4-[[[[2-[[(4-methoxy-2,6-dimethylphenyl)sulfonyl]methylamino]ethoxy]acetyl]methylamino]methyl]phenyl]-1H-imidazole-1-carboxylic acid 1,1-dimethylethyl ester
CAS No.:633698-77-8
Molecular Formula:C₃₀H₄₂N₄O₇S
Molecular Weight:602.752
Hs Code.:

4,5-dihydro-2-[4-[[[[2-[[(4-methoxy-2,6-dimethylphenyl)sulfonyl]methylamino]ethoxy]acetyl]methylamino]methyl]phenyl]-1H-imidazole-1-carboxylic acid 1,1-dimethylethyl ester

Synonyms:4,5-dihydro-2-[4-[[[[2-[[(4-methoxy-2,6-dimethylphenyl)sulfonyl]methylamino]ethoxy]acetyl]methylamino]methyl]phenyl]-1H-imidazole-1-carboxylic acid 1,1-dimethylethyl ester

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Chemical Property of 4,5-dihydro-2-[4-[[[[2-[[(4-methoxy-2,6-dimethylphenyl)sulfonyl]methylamino]ethoxy]acetyl]methylamino]methyl]phenyl]-1H-imidazole-1-carboxylic acid 1,1-dimethylethyl ester

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Technology Process of 4,5-dihydro-2-[4-[[[[2-[[(4-methoxy-2,6-dimethylphenyl)sulfonyl]methylamino]ethoxy]acetyl]methylamino]methyl]phenyl]-1H-imidazole-1-carboxylic acid 1,1-dimethylethyl ester

There total 11 articles about 4,5-dihydro-2-[4-[[[[2-[[(4-methoxy-2,6-dimethylphenyl)sulfonyl]methylamino]ethoxy]acetyl]methylamino]methyl]phenyl]-1H-imidazole-1-carboxylic acid 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 633698-75-6
4,5-dihydro-2-[4-[[methyl[[2-(methylamino)ethoxy]acetyl]amino]methyl]phenyl]-1H-imidazole-1-carboxylic acid 1,1-dimethylethyl ester

: 55661-08-0
4-methoxy-2,6-dimethylbenzenesulfonyl chloride

: 633698-77-8
4,5-dihydro-2-[4-[[[[2-[[(4-methoxy-2,6-dimethylphenyl)sulfonyl]methylamino]ethoxy]acetyl]methylamino]methyl]phenyl]-1H-imidazole-1-carboxylic acid 1,1-dimethylethyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1021/jm2016057

Reference yield: 74.0%

: 633698-77-8
4,5-dihydro-2-[4-[[[[2-[[(4-methoxy-2,6-dimethylphenyl)sulfonyl]methylamino]ethoxy]acetyl]methylamino]methyl]phenyl]-1H-imidazole-1-carboxylic acid 1,1-dimethylethyl ester

Guidance literature:

Reference yield:

: 441295-89-2
[(4-cyanophenyl)methyl]methylcarbamic acid phenylmethyl ester

: 633698-77-8
4,5-dihydro-2-[4-[[[[2-[[(4-methoxy-2,6-dimethylphenyl)sulfonyl]methylamino]ethoxy]acetyl]methylamino]methyl]phenyl]-1H-imidazole-1-carboxylic acid 1,1-dimethylethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: sulfur / 2 h / 100 °C

2: dmap / dichloromethane / 2 h / 20 °C

3: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 20 °C / 760.05 Torr

4: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 15 h / 20 °C

5: palladium 10% on activated carbon; hydrogen / methanol / 3 h / 20 °C / 760.05 Torr

6: triethylamine / dichloromethane / 2 h / 20 °C

With dmap; 1-hydroxy-7-aza-benzotriazole; palladium 10% on activated carbon; hydrogen; sulfur; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In methanol; dichloromethane;
DOI:10.1021/jm2016057