(6R)-(-)-4,10-DIMETHYL-7-ISOPROPYL-1,5-DIOXASPIRO[5.5]UNDEC-3-EN-2-ON

Base Information

• Chemical Name: (6R)-(-)-4,10-DIMETHYL-7-ISOPROPYL-1,5-DIOXASPIRO[5.5]UNDEC-3-EN-2-ON
• CAS No.: 105367-62-2
• Molecular Formula: C₁₄H₂₂O₃
• Molecular Weight: 238.327
• Hs Code.: 2932999099
• Mol file: 105367-62-2.mol

Synonyms:1,5-Dioxaspiro[5.5]undec-3-en-2-one,4,10-dimethyl-7-(1-methylethyl)-, [6R-(6a,7b,10a)]-

Chemical Property of (6R)-(-)-4,10-DIMETHYL-7-ISOPROPYL-1,5-DIOXASPIRO[5.5]UNDEC-3-EN-2-ON

Chemical Property:

• PSA: 35.53000
• LogP: 3.25210

Purity/Quality:

(-)-(6R)-4,10-DIMETHYL-7-ISOPROPYL-1,5-DIOXASPIRO[5.5] UNDEC-EN-2-ONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (6R)-(-)-4,10-DIMETHYL-7-ISOPROPYL-1,5-DIOXASPIRO[5.5]UNDEC-3-EN-2-ON

There total 6 articles about (6R)-(-)-4,10-DIMETHYL-7-ISOPROPYL-1,5-DIOXASPIRO[5.5]UNDEC-3-EN-2-ON which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

4-methyleneoxetan-2-one (674-82-8,2130-41-8) + (2R,5S)-menthone (10458-14-7,14073-97-3,17627-49-5,7786-64-3) → 1'(R),6-Dimethyl-4'(S)-isopropyl-4-oxospiro--dioxin> (105367-62-2) + 1'(R),6-Dimethyl-4'(S)-isopropyl-4-oxospiro--dioxin> (105252-84-4)

Guidance literature:

With toluene-4-sulfonic acid; at 80 ℃; for 24h;

Reference yield:

4-methyleneoxetan-2-one (674-82-8,2130-41-8) + (2R,5S)-menthone (10458-14-7,14073-97-3,17627-49-5,7786-64-3) → 1'(R),6-Dimethyl-4'(S)-isopropyl-4-oxospiro--dioxin> (105367-62-2) + 1'(R),6-Dimethyl-4'(S)-isopropyl-4-oxospiro--dioxin> (105252-84-4) + 2-<4'-Isopropyl-1'(R)-methylcyclohex-3'-en-3'-yloxycarbonylmethyl>-2,6-dimethyl-4-oxo-4H-1,3-dioxin

Guidance literature:

With toluene-4-sulfonic acid; at 80 ℃; for 24h;

Reference yield:

7-isopropyl-10-methyl-1,5-dioxaspiro[5.5]undecane-2,4-dione (105252-83-3) + acetyl chloride (75-36-5) → 1'(R),6-Dimethyl-4'(S)-isopropyl-4-oxospiro--dioxin> (105367-62-2) + 1'(R),6-Dimethyl-4'(S)-isopropyl-4-oxospiro--dioxin> (105252-84-4)

Guidance literature:

Yield given. Multistep reaction. Yields of byproduct given; 1) pyridine, 2) diglyme, 120 deg C;

upstream raw materials:

4-methyleneoxetan-2-one

(2R,5S)-menthone

tert-butyl acetoacetate

7-isopropyl-10-methyl-1,5-dioxaspiro[5.5]undecane-2,4-dione

Downstream raw materials:

(6R,7S,10R)-4-[(2S,4S)-5-[2-((2S,6R)-6-Benzyloxymethyl-4,4-dimethoxy-tetrahydro-pyran-2-ylmethyl)-[1,3]dithian-2-yl]-4-(tert-butyl-dimethyl-silanyloxy)-2-hydroxy-5-methyl-hexyl]-7-isopropyl-10-methyl-1,5-dioxa-spiro[5.5]undec-3-en-2-one

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