(3S,5S)-ethyl-5-(tert-butyldimethylsilyloxy)-3-hydroxy-7-(4-methoxybenzyloxy)-4,4-dimethylheptanoate

Base Information

Chemical Name:(3S,5S)-ethyl-5-(tert-butyldimethylsilyloxy)-3-hydroxy-7-(4-methoxybenzyloxy)-4,4-dimethylheptanoate
CAS No.:1351977-19-9
Molecular Formula:C₂₅H₄₄O₆Si
Molecular Weight:468.706
Hs Code.:

Synonyms:(3S,5S)-ethyl-5-(tert-butyldimethylsilyloxy)-3-hydroxy-7-(4-methoxybenzyloxy)-4,4-dimethylheptanoate

Suppliers and Price of (3S,5S)-ethyl-5-(tert-butyldimethylsilyloxy)-3-hydroxy-7-(4-methoxybenzyloxy)-4,4-dimethylheptanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3S,5S)-ethyl-5-(tert-butyldimethylsilyloxy)-3-hydroxy-7-(4-methoxybenzyloxy)-4,4-dimethylheptanoate

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Technology Process of (3S,5S)-ethyl-5-(tert-butyldimethylsilyloxy)-3-hydroxy-7-(4-methoxybenzyloxy)-4,4-dimethylheptanoate

There total 10 articles about (3S,5S)-ethyl-5-(tert-butyldimethylsilyloxy)-3-hydroxy-7-(4-methoxybenzyloxy)-4,4-dimethylheptanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 64-17-5
ethanol

: 1351977-04-2
(2S,3R)-3-((S)-3-(tert-butyldimethylsilyloxy)-5-(4-methoxybenzyloxy)-2-methylpentan-2-yl)-oxirane-2-carbaldehyde

: 1351977-19-9
(3S,5S)-ethyl-5-(tert-butyldimethylsilyloxy)-3-hydroxy-7-(4-methoxybenzyloxy)-4,4-dimethylheptanoate

Guidance literature:: With 3-benzyl-4,5-dimethylthiazol-3-ium chloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 - 30 ℃;
DOI:10.1002/chem.201302197

Reference yield:

: 64-17-5
ethanol

: C₂₃H₃₈O₅Si

: C₂₅H₄₄O₆Si

: 1351977-19-9
(3S,5S)-ethyl-5-(tert-butyldimethylsilyloxy)-3-hydroxy-7-(4-methoxybenzyloxy)-4,4-dimethylheptanoate

Guidance literature:: With 3-benzyl-4,5-dimethylthiazol-3-ium chloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 30 ℃; for 15h; Inert atmosphere;
DOI:10.1021/ol203130b

Reference yield:

: 1351977-03-1
C₂₃H₄₀O₅Si

: 1351977-19-9
(3S,5S)-ethyl-5-(tert-butyldimethylsilyloxy)-3-hydroxy-7-(4-methoxybenzyloxy)-4,4-dimethylheptanoate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane / 2 h / 20 °C

2: N-ethyl-N,N-diisopropylamine; 3-benzyl-4,5-dimethylthiazol-3-ium chloride / dichloromethane / 20 - 30 °C

With sodium hydrogencarbonate; Dess-Martin periodane; 3-benzyl-4,5-dimethylthiazol-3-ium chloride; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1002/chem.201302197