diethyl {(1R,3S,4R)-4-[(tert-butoxycarbonyl)amino]-3-[4-(trifluoromethyl)phenyl]cyclohexyl}malonate

Base Information

Chemical Name:diethyl {(1R,3S,4R)-4-[(tert-butoxycarbonyl)amino]-3-[4-(trifluoromethyl)phenyl]cyclohexyl}malonate
CAS No.:1316756-61-2
Molecular Formula:C₂₅H₃₄F₃NO₆
Molecular Weight:501.543
Hs Code.:

Synonyms:diethyl {(1R,3S,4R)-4-[(tert-butoxycarbonyl)amino]-3-[4-(trifluoromethyl)phenyl]cyclohexyl}malonate

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Chemical Property of diethyl {(1R,3S,4R)-4-[(tert-butoxycarbonyl)amino]-3-[4-(trifluoromethyl)phenyl]cyclohexyl}malonate

Chemical Property:

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Technology Process of diethyl {(1R,3S,4R)-4-[(tert-butoxycarbonyl)amino]-3-[4-(trifluoromethyl)phenyl]cyclohexyl}malonate

There total 5 articles about diethyl {(1R,3S,4R)-4-[(tert-butoxycarbonyl)amino]-3-[4-(trifluoromethyl)phenyl]cyclohexyl}malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1316756-60-1
(1S,3S,4R)-4-[(tert-butoxycarbonyl)amino]-3-[4-(trifluoromethyl)phenyl]cyclohexyl methanesulfonate

: 105-53-3
diethyl malonate

: 1316756-61-2
diethyl {(1R,3S,4R)-4-[(tert-butoxycarbonyl)amino]-3-[4-(trifluoromethyl)phenyl]cyclohexyl}malonate

Guidance literature:: diethyl malonate; With sodium hydride; In 1,2-dimethoxyethane; at 20 ℃; for 2h;

(1S,3S,4R)-4-[(tert-butoxycarbonyl)amino]-3-[4-(trifluoromethyl)phenyl]cyclohexyl methanesulfonate; In 1,2-dimethoxyethane; for 36h; Reflux;

Reference yield:

: 402-51-7
4-(trifluoromethyl)phenylmagnesium bromide

: 1316756-61-2
diethyl {(1R,3S,4R)-4-[(tert-butoxycarbonyl)amino]-3-[4-(trifluoromethyl)phenyl]cyclohexyl}malonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: copper(I) bromide dimethylsulfide complex / tetrahydrofuran / 1.5 h / -78 °C

1.2: 0.17 h

2.1: L-Selectride / tetrahydrofuran / 18 h / -78 - 20 °C

3.1: triethylamine / dichloromethane / 1.5 h / 0 - 20 °C

4.1: sodium hydride / 1,2-dimethoxyethane / 2 h / 20 °C

4.2: 36 h / Reflux

With copper(I) bromide dimethylsulfide complex; L-Selectride; sodium hydride; triethylamine; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane;

Reference yield:

: 1316756-58-7
tert-butyl {(1R,2S)-4-oxo-2-[4-(trifluoromethyl)phenyl]cyclohexyl}carbamate

: 1316756-61-2
diethyl {(1R,3S,4R)-4-[(tert-butoxycarbonyl)amino]-3-[4-(trifluoromethyl)phenyl]cyclohexyl}malonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: L-Selectride / tetrahydrofuran / 18 h / -78 - 20 °C

2.1: triethylamine / dichloromethane / 1.5 h / 0 - 20 °C

3.1: sodium hydride / 1,2-dimethoxyethane / 2 h / 20 °C

3.2: 36 h / Reflux

With L-Selectride; sodium hydride; triethylamine; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane;