4-[(1-hydroxycyclopropyl)ethynyl]-N-(1-methyl-2-{[(2-methylpropyl)amino]methyl}-1H-indol-5-yl)benzamide

Base Information

Chemical Name:4-[(1-hydroxycyclopropyl)ethynyl]-N-(1-methyl-2-{[(2-methylpropyl)amino]methyl}-1H-indol-5-yl)benzamide
CAS No.:1314127-08-6
Molecular Formula:C₂₆H₂₉N₃O₂
Molecular Weight:415.535
Hs Code.:

Synonyms:4-[(1-hydroxycyclopropyl)ethynyl]-N-(1-methyl-2-{[(2-methylpropyl)amino]methyl}-1H-indol-5-yl)benzamide

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Chemical Property of 4-[(1-hydroxycyclopropyl)ethynyl]-N-(1-methyl-2-{[(2-methylpropyl)amino]methyl}-1H-indol-5-yl)benzamide

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Technology Process of 4-[(1-hydroxycyclopropyl)ethynyl]-N-(1-methyl-2-{[(2-methylpropyl)amino]methyl}-1H-indol-5-yl)benzamide

There total 5 articles about 4-[(1-hydroxycyclopropyl)ethynyl]-N-(1-methyl-2-{[(2-methylpropyl)amino]methyl}-1H-indol-5-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1314128-07-8
4-bromo-N-(1-methyl-2-{[(2-methylpropyl)amino]methyl}-1H-indol-5-yl)benzamide

: 22935-35-9
1-ethynylcyclopropan-1-ol

: 1314127-08-6
4-[(1-hydroxycyclopropyl)ethynyl]-N-(1-methyl-2-{[(2-methylpropyl)amino]methyl}-1H-indol-5-yl)benzamide

Guidance literature:: With pyridine; triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triphenylphosphine; at 65 ℃; for 15h; Inert atmosphere;

Reference yield:

: 71056-58-1
5-amino-1-methyl-1H-indole-2-carboxylic acid ethyl ester

: 1314127-08-6
4-[(1-hydroxycyclopropyl)ethynyl]-N-(1-methyl-2-{[(2-methylpropyl)amino]methyl}-1H-indol-5-yl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 4.5 h / 5 - 20 °C

1.2: 0.5 h / 20 °C

2.1: sodium hydroxide / water; tetrahydrofuran / 16 h / 5 - 20 °C

3.1: triethylamine; dimethyl sulfoxide; sulfur trioxide pyridine complex / 22 h / 20 °C

4.1: acetic acid / ISOPROPYLAMIDE / 1 h / 20 °C

4.2: 15 h / 20 °C

4.3: Cooling with ice

5.1: triethylamine; pyridine / triphenylphosphine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / 15 h / 65 °C / Inert atmosphere

With pyridine; lithium aluminium tetrahydride; sulfur trioxide pyridine complex; acetic acid; dimethyl sulfoxide; triethylamine; sodium hydroxide; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triphenylphosphine; In tetrahydrofuran; ISOPROPYLAMIDE; water;

Reference yield:

: 500015-33-8
(5-Amino-1-methyl-1H-indol-2-yl)methanol

: 1314127-08-6
4-[(1-hydroxycyclopropyl)ethynyl]-N-(1-methyl-2-{[(2-methylpropyl)amino]methyl}-1H-indol-5-yl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide / water; tetrahydrofuran / 16 h / 5 - 20 °C

2.1: triethylamine; dimethyl sulfoxide; sulfur trioxide pyridine complex / 22 h / 20 °C

3.1: acetic acid / ISOPROPYLAMIDE / 1 h / 20 °C

3.2: 15 h / 20 °C

3.3: Cooling with ice

4.1: triethylamine; pyridine / triphenylphosphine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / 15 h / 65 °C / Inert atmosphere

With pyridine; sulfur trioxide pyridine complex; acetic acid; dimethyl sulfoxide; triethylamine; sodium hydroxide; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triphenylphosphine; In tetrahydrofuran; ISOPROPYLAMIDE; water;