4-bromo-N-(1-methyl-2-{[(2-methylpropyl)amino]methyl}-1H-indol-5-yl)benzamide

Base Information

Chemical Name:4-bromo-N-(1-methyl-2-{[(2-methylpropyl)amino]methyl}-1H-indol-5-yl)benzamide
CAS No.:1314128-07-8
Molecular Formula:C₂₁H₂₄BrN₃O
Molecular Weight:414.345
Hs Code.:

Synonyms:4-bromo-N-(1-methyl-2-{[(2-methylpropyl)amino]methyl}-1H-indol-5-yl)benzamide

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Chemical Property of 4-bromo-N-(1-methyl-2-{[(2-methylpropyl)amino]methyl}-1H-indol-5-yl)benzamide

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Technology Process of 4-bromo-N-(1-methyl-2-{[(2-methylpropyl)amino]methyl}-1H-indol-5-yl)benzamide

There total 4 articles about 4-bromo-N-(1-methyl-2-{[(2-methylpropyl)amino]methyl}-1H-indol-5-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 1314128-06-7
4-bromo-N-(2-formyl-1-methyl-1H-indol-5-yl)benzamide

: 78-81-9
isobutylamine

: 1314128-07-8
4-bromo-N-(1-methyl-2-{[(2-methylpropyl)amino]methyl}-1H-indol-5-yl)benzamide

Guidance literature:: 4-bromo-N-(2-formyl-1-methyl-1H-indol-5-yl)benzamide; isobutylamine; With acetic acid; In ISOPROPYLAMIDE; at 20 ℃; for 1h;

With sodium tris(acetoxy)borohydride; In ISOPROPYLAMIDE; at 20 ℃; for 15h;

With sodium hydroxide; In ISOPROPYLAMIDE; water; Cooling with ice;

Reference yield:

: 71056-58-1
5-amino-1-methyl-1H-indole-2-carboxylic acid ethyl ester

: 1314128-07-8
4-bromo-N-(1-methyl-2-{[(2-methylpropyl)amino]methyl}-1H-indol-5-yl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 4.5 h / 5 - 20 °C

1.2: 0.5 h / 20 °C

2.1: sodium hydroxide / water; tetrahydrofuran / 16 h / 5 - 20 °C

3.1: triethylamine; dimethyl sulfoxide; sulfur trioxide pyridine complex / 22 h / 20 °C

4.1: acetic acid / ISOPROPYLAMIDE / 1 h / 20 °C

4.2: 15 h / 20 °C

4.3: Cooling with ice

With lithium aluminium tetrahydride; sulfur trioxide pyridine complex; acetic acid; dimethyl sulfoxide; triethylamine; sodium hydroxide; In tetrahydrofuran; ISOPROPYLAMIDE; water;

Reference yield:

: 500015-33-8
(5-Amino-1-methyl-1H-indol-2-yl)methanol

: 1314128-07-8
4-bromo-N-(1-methyl-2-{[(2-methylpropyl)amino]methyl}-1H-indol-5-yl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / water; tetrahydrofuran / 16 h / 5 - 20 °C

2.1: triethylamine; dimethyl sulfoxide; sulfur trioxide pyridine complex / 22 h / 20 °C

3.1: acetic acid / ISOPROPYLAMIDE / 1 h / 20 °C

3.2: 15 h / 20 °C

3.3: Cooling with ice

With sulfur trioxide pyridine complex; acetic acid; dimethyl sulfoxide; triethylamine; sodium hydroxide; In tetrahydrofuran; ISOPROPYLAMIDE; water;