(S)-N-Cyclohexyl-1-phenylethanamine

Base Information

Chemical Name:(S)-N-Cyclohexyl-1-phenylethanamine
CAS No.:66399-53-9
Molecular Formula:C₁₄H₂₁N
Molecular Weight:203.327
Hs Code.:
DSSTox Substance ID:DTXSID401258456
Nikkaji Number:J1.806.332H

Synonyms:DTXSID401258456;(S)-N-Cyclohexyl-1-phenylethanamine;AKOS013181123;(alphaS)-N-Cyclohexyl-alpha-methylbenzenemethanamine;66399-53-9

Suppliers and Price of (S)-N-Cyclohexyl-1-phenylethanamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 0 raw suppliers

Chemical Property of (S)-N-Cyclohexyl-1-phenylethanamine

Chemical Property:

XLogP3:3.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:3
Exact Mass:203.167399674
Heavy Atom Count:15
Complexity:166

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C1=CC=CC=C1)NC2CCCCC2
Isomeric SMILES:C[C@@H](C1=CC=CC=C1)NC2CCCCC2

Technology Process of (S)-N-Cyclohexyl-1-phenylethanamine

There total 8 articles about (S)-N-Cyclohexyl-1-phenylethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6
styrene

: 66399-53-9
(1S,αS)-N-(1-phenylethyl)cyclohexanamine

Guidance literature:: Multi-step reaction with 3 steps

1: chiral rhodium(I) complex / tetrahydrofuran / 1 h / 20 °C

2: toluene / 2 h

3: toluene; diethyl ether / 1.08 h / 0 - 20 °C

chiral rhodium(I); In tetrahydrofuran; diethyl ether; toluene; 1: Addition / 2: Substitution / 3: Alkylation;

Reference yield:

: 108-91-8,157973-60-9
cyclohexylamine

: 66399-53-9
(1S,αS)-N-(1-phenylethyl)cyclohexanamine

Guidance literature:: Multi-step reaction with 2 steps

1: aq. NaOCl / diethyl ether / 0 °C

2: toluene; diethyl ether / 1.08 h / 0 - 20 °C

With sodium hypochlorite; In diethyl ether; toluene; 1: Chlorination / 2: Alkylation;

Reference yield:

: 731797-80-1
N-(1-phenylethylidene)cycloexanamine

: 66399-53-9
(1S,αS)-N-(1-phenylethyl)cyclohexanamine

: 147021-76-9
(1R,αR)-N-(1-phenylethyl)cyclohexanamine

Guidance literature:: With C₂₁H₃₄BN₂O₂⁽¹⁺⁾*C₂F₆NO₄S₂^(1-); hydrogen; at 30 ℃; for 16h; under 75757.6 Torr; Overall yield = 67 %; enantioselective reaction; Glovebox; Sealed tube;
DOI:10.1039/c9cc02900a