1-(5-(7-chloro-2-methyl-1,6-naphthyridin-3-yl)-2-fluoro-4-methylphenyl)-3-(2-cyclobutylethyl)urea

Base Information

Chemical Name:1-(5-(7-chloro-2-methyl-1,6-naphthyridin-3-yl)-2-fluoro-4-methylphenyl)-3-(2-cyclobutylethyl)urea
CAS No.:1455038-64-8
Molecular Formula:C₂₃H₂₄ClFN₄O
Molecular Weight:426.921
Hs Code.:

Synonyms:1-(5-(7-chloro-2-methyl-1,6-naphthyridin-3-yl)-2-fluoro-4-methylphenyl)-3-(2-cyclobutylethyl)urea

Suppliers and Price of 1-(5-(7-chloro-2-methyl-1,6-naphthyridin-3-yl)-2-fluoro-4-methylphenyl)-3-(2-cyclobutylethyl)urea

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-(5-(7-chloro-2-methyl-1,6-naphthyridin-3-yl)-2-fluoro-4-methylphenyl)-3-(2-cyclobutylethyl)urea

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-(5-(7-chloro-2-methyl-1,6-naphthyridin-3-yl)-2-fluoro-4-methylphenyl)-3-(2-cyclobutylethyl)urea

There total 12 articles about 1-(5-(7-chloro-2-methyl-1,6-naphthyridin-3-yl)-2-fluoro-4-methylphenyl)-3-(2-cyclobutylethyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1455035-98-9
5-(7-chloro-2-methyl[1,6]naphthyridin-3-yl)-2-fluoro-4-methylaniline

: 4415-84-3
3-cyclobutylpropionic acid

: 1455038-64-8
1-(5-(7-chloro-2-methyl-1,6-naphthyridin-3-yl)-2-fluoro-4-methylphenyl)-3-(2-cyclobutylethyl)urea

Guidance literature:: With diphenyl phosphoryl azide; triethylamine; In 1,4-dioxane; at 20 - 90 ℃; for 4.5h;

Reference yield:

: 40296-46-6
ethyl 4,6-dichloronicotinate

: 1455038-64-8
1-(5-(7-chloro-2-methyl-1,6-naphthyridin-3-yl)-2-fluoro-4-methylphenyl)-3-(2-cyclobutylethyl)urea

Guidance literature:: Multi-step reaction with 8 steps

1: triethylamine / dimethyl sulfoxide / 20 °C

2: trifluoroacetic acid / 50 °C

3: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

4: manganese(IV) oxide / dichloromethane / 20 °C

5: potassium hydroxide / tetrahydrofuran / 1 h / 20 °C

6: pyridine / dichloromethane / 2 h / 0 °C / Inert atmosphere

7: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 60 °C / Inert atmosphere

8: diphenyl phosphoryl azide; triethylamine / 1,4-dioxane / 4.5 h / 20 - 90 °C

With pyridine; manganese(IV) oxide; lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; diphenyl phosphoryl azide; potassium carbonate; triethylamine; trifluoroacetic acid; potassium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; dimethyl sulfoxide; 8: |Curtius Rearrangement;

Reference yield:

: 1391740-89-8
ethyl 6-chloro-4-[(4-methoxyphenyl)methylamino]pyridine-3-carboxylate

: 1455038-64-8
1-(5-(7-chloro-2-methyl-1,6-naphthyridin-3-yl)-2-fluoro-4-methylphenyl)-3-(2-cyclobutylethyl)urea

Guidance literature:: Multi-step reaction with 7 steps

1: trifluoroacetic acid / 50 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

3: manganese(IV) oxide / dichloromethane / 20 °C

4: potassium hydroxide / tetrahydrofuran / 1 h / 20 °C

5: pyridine / dichloromethane / 2 h / 0 °C / Inert atmosphere

6: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 60 °C / Inert atmosphere

7: diphenyl phosphoryl azide; triethylamine / 1,4-dioxane / 4.5 h / 20 - 90 °C

With pyridine; manganese(IV) oxide; lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; diphenyl phosphoryl azide; potassium carbonate; triethylamine; trifluoroacetic acid; potassium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; 7: |Curtius Rearrangement;