2-[2-(4'-chlorobiphenyl-4-sulfonyl)ethoxy]naphthalene-1-carboxylic acid

Base Information

Chemical Name:2-[2-(4'-chlorobiphenyl-4-sulfonyl)ethoxy]naphthalene-1-carboxylic acid
CAS No.:279245-97-5
Molecular Formula:C₂₅H₁₉ClO₅S
Molecular Weight:466.942
Hs Code.:

Synonyms:2-[2-(4'-chlorobiphenyl-4-sulfonyl)ethoxy]naphthalene-1-carboxylic acid

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Chemical Property of 2-[2-(4'-chlorobiphenyl-4-sulfonyl)ethoxy]naphthalene-1-carboxylic acid

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Technology Process of 2-[2-(4'-chlorobiphenyl-4-sulfonyl)ethoxy]naphthalene-1-carboxylic acid

There total 9 articles about 2-[2-(4'-chlorobiphenyl-4-sulfonyl)ethoxy]naphthalene-1-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 279245-96-4
2-[2-(4'-chlorobiphenyl-4-sulfonyl)ethoxy]naphthalene-1-carboxylic acid benzyl ester

: 279245-97-5
2-[2-(4'-chlorobiphenyl-4-sulfonyl)ethoxy]naphthalene-1-carboxylic acid

Guidance literature:: With hydrogen; acetic acid; 10percent Pd/C; In tetrahydrofuran; at 20 ℃; for 20h;
DOI:10.1021/jm020160g

Reference yield:

: 14703-92-5
4-(2-hydroxyethylthio)bromobenzene

: 279245-97-5
2-[2-(4'-chlorobiphenyl-4-sulfonyl)ethoxy]naphthalene-1-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: CsF; tetrakis(triphenylphosphine)palladium⁽⁰⁾ / 1,2-dimethoxy-ethane / 16 h / Heating

2: Et₃N / CH₂Cl₂ / 1 h / 0 °C

3: NaH / dimethylformamide / 4 h / 50 °C

4: 43 percent / mCPBA / CH₂Cl₂ / 16 h / Heating

5: 58 percent / H₂; AcOH / 10percent Pd/C / tetrahydrofuran / 20 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen; sodium hydride; acetic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; cesium fluoride; 10percent Pd/C; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide; 1: Suzuki coupling;
DOI:10.1021/jm020160g

Reference yield:

: 1679-18-1
4-Chlorophenylboronic acid

: 279245-97-5
2-[2-(4'-chlorobiphenyl-4-sulfonyl)ethoxy]naphthalene-1-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: CsF; tetrakis(triphenylphosphine)palladium⁽⁰⁾ / 1,2-dimethoxy-ethane / 16 h / Heating

2: Et₃N / CH₂Cl₂ / 1 h / 0 °C

3: NaH / dimethylformamide / 4 h / 50 °C

4: 43 percent / mCPBA / CH₂Cl₂ / 16 h / Heating

5: 58 percent / H₂; AcOH / 10percent Pd/C / tetrahydrofuran / 20 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen; sodium hydride; acetic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; cesium fluoride; 10percent Pd/C; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide; 1: Suzuki coupling;
DOI:10.1021/jm020160g