(4-cyclopropyl-3,4-dihydroquinoxalin-1(2H)-yl)(1-((2,5-dichloro-4-iodophenoxy)methyl)cyclopropyl)methanone

Base Information

Chemical Name:(4-cyclopropyl-3,4-dihydroquinoxalin-1(2H)-yl)(1-((2,5-dichloro-4-iodophenoxy)methyl)cyclopropyl)methanone
CAS No.:1445985-67-0
Molecular Formula:C₂₂H₂₁Cl₂IN₂O₂
Molecular Weight:543.231
Hs Code.:

Synonyms:(4-cyclopropyl-3,4-dihydroquinoxalin-1(2H)-yl)(1-((2,5-dichloro-4-iodophenoxy)methyl)cyclopropyl)methanone

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Chemical Property of (4-cyclopropyl-3,4-dihydroquinoxalin-1(2H)-yl)(1-((2,5-dichloro-4-iodophenoxy)methyl)cyclopropyl)methanone

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Technology Process of (4-cyclopropyl-3,4-dihydroquinoxalin-1(2H)-yl)(1-((2,5-dichloro-4-iodophenoxy)methyl)cyclopropyl)methanone

There total 12 articles about (4-cyclopropyl-3,4-dihydroquinoxalin-1(2H)-yl)(1-((2,5-dichloro-4-iodophenoxy)methyl)cyclopropyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 7587-15-7
2,3-dichloro-4-iodophenol

: 1445985-66-9
(1-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)cyclopropyl)methyl methanesulfonate

: 1445985-67-0
(4-cyclopropyl-3,4-dihydroquinoxalin-1(2H)-yl)(1-((2,5-dichloro-4-iodophenoxy)methyl)cyclopropyl)methanone

Guidance literature:: With potassium carbonate; In acetone; at 55 ℃;

Reference yield:

: 1224640-11-2
1-cyclopropyl-4-hydroxy-1,2,3,4-tetrahydroquinoxaline-2,3-dione

: 1445985-67-0
(4-cyclopropyl-3,4-dihydroquinoxalin-1(2H)-yl)(1-((2,5-dichloro-4-iodophenoxy)methyl)cyclopropyl)methanone

Guidance literature:: Multi-step reaction with 8 steps

1: triphenylphosphine / N,N-dimethyl-formamide / 2 h / 135 °C / Inert atmosphere

2: borane-THF / tetrahydrofuran / 4 h / 50 °C

3: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C

4: water; sodium hydroxide / tetrahydrofuran / 0 - 20 °C

5: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C

6: sodium tetrahydroborate / 1,2-dimethoxyethane; water / 2 h / 0 °C

7: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C

8: potassium carbonate / acetone / 55 °C

With sodium tetrahydroborate; borane-THF; water; potassium carbonate; triethylamine; triphenylphosphine; sodium hydroxide; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide; acetone;

Reference yield:

: 1224640-12-3
1-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-2,3-dione

: 1445985-67-0
(4-cyclopropyl-3,4-dihydroquinoxalin-1(2H)-yl)(1-((2,5-dichloro-4-iodophenoxy)methyl)cyclopropyl)methanone

Guidance literature:: Multi-step reaction with 7 steps

1: borane-THF / tetrahydrofuran / 4 h / 50 °C

2: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C

3: water; sodium hydroxide / tetrahydrofuran / 0 - 20 °C

4: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C

5: sodium tetrahydroborate / 1,2-dimethoxyethane; water / 2 h / 0 °C

6: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C

7: potassium carbonate / acetone / 55 °C

With sodium tetrahydroborate; borane-THF; water; potassium carbonate; triethylamine; sodium hydroxide; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; acetone;