[mono[N-succinoyl][(valinyl)-5-fluorouridine]-bis[N-succinoyl] (benzyloxy)amino butyl] isocyanurate

Base Information

Chemical Name:[mono[N-succinoyl][(valinyl)-5-fluorouridine]-bis[N-succinoyl] (benzyloxy)amino butyl] isocyanurate
CAS No.:261783-78-2
Molecular Formula:C₆₂H₇₈FN₉O₂₁
Molecular Weight:1304.35
Hs Code.:

Synonyms:[mono[N-succinoyl][(valinyl)-5-fluorouridine]-bis[N-succinoyl] (benzyloxy)amino butyl] isocyanurate

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Chemical Property of [mono[N-succinoyl][(valinyl)-5-fluorouridine]-bis[N-succinoyl] (benzyloxy)amino butyl] isocyanurate

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Technology Process of [mono[N-succinoyl][(valinyl)-5-fluorouridine]-bis[N-succinoyl] (benzyloxy)amino butyl] isocyanurate

There total 4 articles about [mono[N-succinoyl][(valinyl)-5-fluorouridine]-bis[N-succinoyl] (benzyloxy)amino butyl] isocyanurate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 153756-36-6
Tris<butyl> isocyanurate

: (S)-2-Amino-3-methyl-butyric acid (2R,3S,4R,5R)-5-(5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl ester; compound with toluene-4-sulfonic acid

: 261783-78-2
[mono[N-succinoyl][(valinyl)-5-fluorouridine]-bis[N-succinoyl] (benzyloxy)amino butyl] isocyanurate

: [bis[N-succinoyl][(valinyl)-5-fluorouridine]mono[N-succinoyl] (benzyloxy)amino butyl] isocyanurate

: 261783-80-6
tris[N-succinoyl[(valinyl)-5-fluorouridine] (benzyloxy)aminobutyl] isocyanurate

Guidance literature:: With dmap; 1-hydroxy-7-aza-benzotriazole; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1016/S0968-0896(99)00248-5

Reference yield:

: 108-30-5
succinic acid anhydride

: 2-[3-(benzyloxy-{4-[3,5-bis-(4-benzyloxyamino-butyl)-2,4,6-trioxo-[1,3,5]triazinan-1-yl]-butyl}-carbamoyl)-propionylamino]-3-methyl-butyric acid 5-(5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl ester

: 261783-78-2
[mono[N-succinoyl][(valinyl)-5-fluorouridine]-bis[N-succinoyl] (benzyloxy)amino butyl] isocyanurate

Guidance literature:: With dmap; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; pH=7.1;
DOI:10.1016/S0968-0896(99)00248-5

Reference yield:

: 153756-35-5
Tris<-N-(benzyloxy)amino>butyl> isocyanurate

: 261783-78-2
[mono[N-succinoyl][(valinyl)-5-fluorouridine]-bis[N-succinoyl] (benzyloxy)amino butyl] isocyanurate

Guidance literature:: Multi-step reaction with 4 steps

1: 15 percent / Zn dust; AcOH / tetrahydrofuran / 0.83 h / 45 - 50 °C

2: 64.2 mg / 1-hydroxy-7-azabenzotriazole; EDC; DMAP / dimethylformamide / 20 °C

3: Cd-Pb couple; aq. NH₄OAc / tetrahydrofuran / pH 7.1

4: 15.2 mg / DMAP / tetrahydrofuran; dimethylformamide / 20 °C / pH 7.1

With dmap; 10% Cd/Pd; 1-hydroxy-7-aza-benzotriazole; ammonium acetate; acetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; zinc; In tetrahydrofuran; N,N-dimethyl-formamide; 1: Acylation / 2: Acylation / 3: Reduction / 4: Acylation;
DOI:10.1016/S0968-0896(99)00248-5