153756-36-6Relevant academic research and scientific papers
Syntheses and studies of multiwarhead siderophore-5-fluorouridine conjugates
Lu, Yong,Miller, Marvin J.
, p. 3025 - 3038 (2007/10/03)
Siderophores are microbial iron chelating agents that sequester physiologically essential iron for microbes. Conjugation of drugs to siderophores allows use of active iron transport for microbially directed drug delivery. Syntheses and biological studies are described of the first multidrug isocyanurate-based siderophore analogues separately containing one, two, and three 5-fluorouridine (5-FU) derivatives as the drug component. The results indicate that a single siderophore can be used to deliver multiple drugs to target pathogenic microorganisms. Copyright (C) 1999 Elsevier Science Ltd.
Iron transport-mediated drug delivery: Synthesis and biological evaluation of cyanuric acid-based siderophore analogs and β-lactam conjugates
Ghosh,Miller
, p. 1020 - 1026 (2007/10/02)
Trihydroxamate-containing isocyanurates 4a-c were synthesized and determined to be capable of substituting for natural siderophores (microbial iron sequestering agents) in limited microbiological assays. The direct coupling of protected 4a to carbacephalosporins 16 and 17 and subsequent deprotection gave conjugates 20 and 21. The Lorabid conjugate 21 was especially active against E. ccoli X580 in preliminary biological tests, thus demonstrating the continued potential of siderophore-mediated drug delivery.
