4-chloro-2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)pyrimidine-5-sulfonyl chloride

Base Information

Chemical Name:4-chloro-2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)pyrimidine-5-sulfonyl chloride
CAS No.:1446358-81-1
Molecular Formula:C₁₉H₁₇FN₆O₄S
Molecular Weight:444.446
Hs Code.:

Synonyms:4-chloro-2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)pyrimidine-5-sulfonyl chloride

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Chemical Property of 4-chloro-2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)pyrimidine-5-sulfonyl chloride

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Technology Process of 4-chloro-2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)pyrimidine-5-sulfonyl chloride

There total 6 articles about 4-chloro-2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)pyrimidine-5-sulfonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1446359-92-7
4-chloro-2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)pyrimidine-5-sulfonyl chloride

: 124-40-3
dimethyl amine

: 1446358-81-1
4-chloro-2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)pyrimidine-5-sulfonyl chloride

Guidance literature:: 4-chloro-2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)pyrimidine-5-sulfonyl chloride; dimethyl amine; In tetrahydrofuran; at 25 ℃; for 0.5h;

With water; In ethyl acetate;

Reference yield:

: 1354041-90-9
2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)pyrimidin-4-ol

: 1446358-81-1
4-chloro-2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)pyrimidine-5-sulfonyl chloride

Guidance literature:: Multi-step reaction with 2 steps

1: chlorosulfonic acid / 0.5 h / 100 °C

2: tetrahydrofuran / 0.5 h / 25 °C

With chlorosulfonic acid; In tetrahydrofuran;

Reference yield:

: 1446353-53-2
C₁₄H₁₀FN₃O₃

: 1446358-81-1
4-chloro-2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)pyrimidine-5-sulfonyl chloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; tert-butylamine / ethyl acetate / -15 °C

1.2: 1 h / 70 °C

2.1: sodium methylate / methanol / 0 - 60 °C

2.2: 20 °C

3.1: 6 h / 90 °C

4.1: chlorosulfonic acid / 0.5 h / 100 °C

5.1: tetrahydrofuran / 0.5 h / 25 °C

With chlorosulfonic acid; sodium methylate; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; tert-butylamine; triethylamine; In tetrahydrofuran; methanol; ethyl acetate;