5-METHYL-1,3-OXAZOLE-4-CARBOXYLIC ACID

Base Information

• Chemical Name: 5-METHYL-1,3-OXAZOLE-4-CARBOXYLIC ACID
• CAS No.: 103879-58-9
• Molecular Formula: C5H5NO3
• Molecular Weight: 127.1
• Hs Code.: 2934999090
• Mol file: 103879-58-9.mol

Synonyms:AC1Q2FNH;AKOS001836446;AG-D-15353;CID11355484;TC-069188;SBB053173;

Chemical Property of 5-METHYL-1,3-OXAZOLE-4-CARBOXYLIC ACID

Chemical Property:

• Vapor Pressure: 0.00263mmHg at 25°C
• Refractive Index: 1.514
• Boiling Point: 274.4 °C at 760 mmHg
• PKA: 3.06±0.31(Predicted)
• Flash Point: 119.7 °C
• PSA: 63.33000
• Density: 1.348 g/cm³
• LogP: 0.68120
• Storage Temp.: 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

5-Methyl-1,3-oxazole-4-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-METHYL-1,3-OXAZOLE-4-CARBOXYLIC ACID

There total 2 articles about 5-METHYL-1,3-OXAZOLE-4-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

5-Methyl-4-oxazolcarbonsaeure-ethylester (32968-44-8) → 5-methyloxazole-4-carboxylic acid (103879-58-9)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; water; at 0 - 25 ℃; for 2.5h;

DOI:10.1002/ejoc.201900032

Reference yield: 82.0%

5-Methyloxazol-4-carbonsaeure-methylester (41172-57-0) → 5-methyloxazole-4-carboxylic acid (103879-58-9)

Guidance literature:

With sodium hydroxide; In methanol; at 40 ℃; for 4h;

DOI:10.1021/ja0621795

Reference yield: 62.9%

2-((4-(trifluoromethyl)phenyl)amino)benzohydrazide + 5-methyloxazole-4-carboxylic acid (103879-58-9) → 5-methyl-N’-(2-((4-(trifluoromethyl)phenyl)amino)benzoyl)oxazole-4-carbohydrazide

Guidance literature:

With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

upstream raw materials:

5-Methyloxazol-4-carbonsaeure-methylester

5-Methyl-4-oxazolcarbonsaeure-ethylester

Refernces

• 1、 Solomin, Vitalii V.,Radchenko, Dmytro S.,Slobodyanyuk, Evgeniy Y.,Geraschenko, Oleksandr V.,Vashchenko, Bohdan V.,Grygorenko, Oleksandr O.. "Widely Exploited, Yet Unreported: Regiocontrolled Synthesis and the Suzuki–Miyaura Reactions of Bromooxazole Building Blocks". . p. 2884 - 2898. Retrieved 2019/03/07.