32968-44-8

Basic information

• Product Name: ETHYL 5-METHYLOXAZOLE-4-CARBOXYLATE
• Synonyms: ETHYL 5-METHYLOXAZOLE-4-CARBOXYLATE;ethyl 5-Methyl-1,3-oxazole-4-carboxylate;Ethyl 5-Methyloxazole-4-Carboxylate(WX618211)
• CAS NO: 32968-44-8
• Molecular Formula: C₇H₉NO₃
• Molecular Weight: 155.15
• Mol File: 32968-44-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 208.5±20.0 °C(Predicted)
• Appearance: /
• Density: 1.139±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: -0.92±0.10(Predicted)
• CAS DataBase Reference: ETHYL 5-METHYLOXAZOLE-4-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 5-METHYLOXAZOLE-4-CARBOXYLATE(32968-44-8)
• EPA Substance Registry System: ETHYL 5-METHYLOXAZOLE-4-CARBOXYLATE(32968-44-8)

Safety Data

• Hazardous Substances Data: 32968-44-8(Hazardous Substances Data)

Usage

Uses

Ethyl 5-Methyl-4-oxazolecarboxylate is used in the synthesis of conglobatin which is a novel macrolide dilactone from Streptomyces conglobatus ATCC 31005.

InChI:InChI=1/C5H5NO3.C2H4O/c1-3-4(5(7)8)6-2-9-3;1-2-3/h2H,1H3,(H,7,8);2H,1H3

Upstream product

• 2999-46-4 Ethyl isocyanoacetate 
• 64-19-7 acetic acid 
• 75-36-5 acetyl chloride 
• 127-17-3 2-oxo-propionic acid 
• 108-24-7 acetic anhydride 

Downstream Products

• 1578154-55-8 (3S)-4-[[(4R)-4-(2-chloro-4-fluoro-phenyl)-5-methoxycarbonyl-2-(5-methyloxazol-4-yl)-1,4-dihydropyrimidin-6-yl]methyl]-morpholine-3-carboxylic acid 
• 1227747-41-2 C₁₇H₁₆N₂O₃S 
• 1227747-62-7 C₂₃H₂₃N₃O₄S 
• 103879-58-9 5-methyloxazole-4-carboxylic acid 
• 956118-40-4 C₅H₅NO₂ 
• 61151-96-0 ethyl 5-methyl-2-phenyloxazole-4-carboxylate 
• 874821-67-7 4-hydroxymethyl-5-methyloxazole 
• 7737-17-9 1-aminopropan-2-one hydrochloride 

Relevant articles and documents

A combinatorially convenient version of synthesis of 5-substituted oxazole-4-carboxylic acid ethyl esters

Reaction of ethyl isocyanoacetic acid with sodium hydride in anhydrous benzene, followed by treatment with carboxylic acid chlorides or N-(acyloxy)pyrrolidine-2,5-diones, gives 5-substituted oxazole-4-carboxylic acid esters. The procedure is applicable to

Synthesis of oxazoles by silver catalysed oxidative decarboxylation-cyclization of α-oxocarboxylates and isocyanides

A silver catalysed synthesis of oxazoles by the oxidative decarboxylation-cyclization of α-oxocarboxylates and isocyanides was developed. This method provided a novel strategy to construct oxazole rings compared to traditional methods. Mechanistic investigations such as operando IR, EPR and radical inhibition experiments were carefully done and confirmed the acyl cation and Ag(ii) as the intermediates in this transformation, and the involvement of a radical decarboxylative process.

Lipophilic 5,6,7,8-tetrahydropterin substrates for phenylalanine hydroxylase (monkey brain), tryptophan hydroxylase (rat brain) and tyrosine hydroxylase (rat brain)

A high yielding unambiguous synthesis of (+/-)-6-alkyl-5,6,7,8-tetrahydropterin 5a-f hydrochlorides starting from ethyl α-isocyanoacetate 1 and the respective alkanoic anhydrides or alkanoyl chlorides in four steps is described.All the six pterins 5a-f that have been synthesised are substrates for mammalian phenylalanine, tryptophan and tyrosine hydroxylases and their activities have been compared with those of natural 6R-tetrahydrobiopterin under similar conditions.The data allowed the choice of 6-n-propyl-5,6,7,8-tetrahydropterin 5c for further studies as a candidate for tetrahydrobiopterin drug therapy.Keywords: (+/-)-6-alkyltetrahydropterinsydroxylase / tryptophan hydroxylase / tyrosine hydroxylase