Acetic acid (3S,4R,5R)-4-methanesulfonyloxy-5-(4-methoxy-benzyl)-2-oxo-pyrrolidin-3-yl ester

Base Information

Chemical Name:Acetic acid (3S,4R,5R)-4-methanesulfonyloxy-5-(4-methoxy-benzyl)-2-oxo-pyrrolidin-3-yl ester
CAS No.:112487-80-6
Molecular Formula:C₁₅H₁₉NO₇S
Molecular Weight:357.384
Hs Code.:

Synonyms:Acetic acid (3S,4R,5R)-4-methanesulfonyloxy-5-(4-methoxy-benzyl)-2-oxo-pyrrolidin-3-yl ester

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Chemical Property of Acetic acid (3S,4R,5R)-4-methanesulfonyloxy-5-(4-methoxy-benzyl)-2-oxo-pyrrolidin-3-yl ester

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Technology Process of Acetic acid (3S,4R,5R)-4-methanesulfonyloxy-5-(4-methoxy-benzyl)-2-oxo-pyrrolidin-3-yl ester

There total 7 articles about Acetic acid (3S,4R,5R)-4-methanesulfonyloxy-5-(4-methoxy-benzyl)-2-oxo-pyrrolidin-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 124-63-0
methanesulfonyl chloride

: 112464-01-4
Acetic acid (3S,4R,5R)-4-hydroxy-5-(4-methoxy-benzyl)-2-oxo-pyrrolidin-3-yl ester

: 112487-80-6
Acetic acid (3S,4R,5R)-4-methanesulfonyloxy-5-(4-methoxy-benzyl)-2-oxo-pyrrolidin-3-yl ester

Guidance literature:: With triethylamine;
DOI:10.1246/cl.1987.697

Reference yield:

: 112463-95-3,114495-30-6,114495-31-7,114495-32-8,114495-33-9
(R)-3-Chloro-4-hydroxy-5-(4-methoxy-benzyl)-pyrrolidin-2-one

: 112487-80-6
Acetic acid (3S,4R,5R)-4-methanesulfonyloxy-5-(4-methoxy-benzyl)-2-oxo-pyrrolidin-3-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: sodium methoxide / methanol / 0 °C

2: 65 percent / BF₃

3: 90 percent / Et₃N

With sodium methylate; triethylamine; boron trifluoride; In methanol;
DOI:10.1246/cl.1987.697

Reference yield:

: 112463-92-0
[(R)-1-Formyl-2-(4-methoxy-phenyl)-ethyl]-carbamic acid methyl ester

: 112487-80-6
Acetic acid (3S,4R,5R)-4-methanesulfonyloxy-5-(4-methoxy-benzyl)-2-oxo-pyrrolidin-3-yl ester

Guidance literature:: Multi-step reaction with 6 steps

1: methyl trichloroacetate, Et₄NOTs / dimethylformamide / carbon rod electrodes, ceramic diaphragm (0.1 A, 20 mF)

2: 1.) HBr, AcOH; 2.) sodium bicarbonate

3: 80 percent / 0.2 M NH₄NO₃ / methanol / 0 °C / Pt cathode, carbon rod anode, 3 F/mol, 0.2 A

4: sodium methoxide / methanol / 0 °C

5: 65 percent / BF₃

6: 90 percent / Et₃N

With ammonium nitrate; Methyl trichloroacetate; hydrogen bromide; sodium methylate; sodium hydrogencarbonate; tetraethylammonium tosylate; acetic acid; triethylamine; boron trifluoride; In methanol; N,N-dimethyl-formamide;
DOI:10.1246/cl.1987.697